Files and links (1)
Author’s VersionCC BY-NC-ND V4.0, Open Access
Journal article
Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia
Veterinary Microbiology, Vol.211, pp.43-50
2017
Abstract
Multidrug-resistant (MDR) Escherichia coli have become a major public health concern to both humans and animal health. While the frequency of antimicrobial resistance (AMR) in clinical E. coli is monitored regularly in human medicine, current frequency of AMR in companion animals remains unknown in Australia. In this study we conducted antimicrobial susceptibility testing (AST) and where possible, determined potential risk factors for MDR infection among 883 clinical Escherichia coli isolated from dogs (n = 514), cats (n = 341) and horses (n = 28). AST was undertaken for 15 antimicrobial agents according to the Clinical Laboratory Standards Institute (CLSI) guidelines and interpreted using epidemiological cut-off values (ECOFFs) as well as CLSI veterinary and human clinical breakpoints. The AST revealed complete absence of resistance to carbapenems while resistance to amikacin was observed at a low level in isolates from dogs (1.6%) and cats (1.5%) compared to horses (10.7%). Among dog isolates, resistance to fluoroquinolones ranged from 9.1%–9.3% whereas among cat isolates, it ranged from 3.2%–5%. Among dog isolates, the proportion showing a 3rd generation cephalosporin (3GC) non-wild type phenotype was significantly higher (P < 0.05) in skin and soft tissue infection (SSTI, n = 122) isolates (17.2%–20.5%) compared to urinary tract infection (UTI, n = 392) isolates (9.9%–10.2%). The frequency of multidrug resistance was 18.1%, 11.7% and 42.9% in dog, cat and horse isolates, respectively. Risk factor analysis revealed that MDR E. coli isolated from UTI were positively associated with chronicity of infection and previous antimicrobial treatment. Dogs and cats with chronic UTI that had been previously treated with antimicrobials were eight times and six times more likely to be infected with MDR E. coli compared to dogs and cats with non-chronic UTI, and no history of antimicrobial treatment, respectively. This study revealed that pre-existing disease condition and prior antimicrobial use were the major risks associated with UTI with MDR E. coli in companion animals.
Details
- Title
- Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia
- Authors/Creators
- S. Saputra (Author/Creator)D. Jordan (Author/Creator)T. Mitchell (Author/Creator)H.S. Wong (Author/Creator)R.J. Abraham (Author/Creator)A. Kidsley (Author/Creator)J. Turnidge (Author/Creator)D.J. Trott (Author/Creator)S. Abraham (Author/Creator)
- Publication Details
- Veterinary Microbiology, Vol.211, pp.43-50
- Publisher
- Elsevier BV
- Identifiers
- 991005540191507891
- Copyright
- © 2017 Elsevier B.V.
- Murdoch Affiliation
- Centre for Biosecurity and One Health; Antimicrobial Resistance and Infectious Disease Laboratory; School of Medical, Molecular and Forensic Sciences; School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
415 File views/ downloads
114 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.146 Antimicrobial Resistance
- Web Of Science research areas
- Microbiology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science