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Journal article
Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study
PLOS ONE, Vol.12(4), e0176379
2017
Abstract
Methicillin-resistant coagulase-positive staphylococci (CoPS) have become increasingly recognised as opportunistic pathogens that limit therapeutic options in companion animals. The frequency of methicillin resistance amongst clinical isolates on an Australia-wide level is unknown. This study determined antimicrobial susceptibility patterns for CoPS isolated from clinical infections in companion animals (dogs, cats and horses) as part of the first nation-wide survey on antimicrobial resistance in animal pathogens in Australia for a oneyear period (January 2013 to January 2014). Clinical Staphylococcus spp. isolates (n = 888) obtained from 22 veterinary diagnostic laboratories were identified by MALDI-TOF mass spectrometry and subjected to antimicrobial susceptibility testing for 16 antimicrobials, representing 12 antimicrobial classes. Potential risk factors associated with methicillin resistance in Staphylococcus pseudintermedius isolates from dogs were analysed based on demographic factors and clinical history, including gender, age, previous antimicrobial treatment, chronic and/or recurrent diseases and site of infections. The most commonly identified CoPS were S. pseudintermedius (70.8%; dogs n = 616, cats n = 13) and S. aureus (13.2%, horses n = 53, dogs n = 47 and cats n = 17). Overall, the frequency of methicillin resistance among S. pseudintermedius (MRSP) and S. aureus (MRSA) was 11.8% and 12.8%, respectively. MRSP isolates were strongly associated with resistance to fluoroquinolones (OR 287; 95%CI 91.2±1144.8) and clindamycin (OR 105.2, 95%CI 48.5±231.9). MRSA isolates from dogs and cats were also more likely to be resistant to fluoroquinolones (OR 5.4, 95%CI 0.6±252.1), whereas MRSA from horses were more likely to be resistant to rifampicin. In multivariate analysis, MRSP-positive status was significantly associated with particular infection sites, including surgical (OR 8.8; 95%CI 3.74±20.7), and skin and soft tissue (OR 3.9; 95%CI 1.97±7.51). S. pseudintermedius isolated from dogs with surgical site infections were three times more likely to be methicillin-resistant if cases had received prior antimicrobial treatment. Whilst the survey results indicate the proportion of CoPS obtained from Australian companion animals that are methicillin-resistant is currently moderate, the identified risk factors suggest that it could rapidly increase without adequate biosecurity and infection control procedures in veterinary practice.
Details
- Title
- Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study
- Authors/Creators
- S. Saputra (Author/Creator) - The University of AdelaideD. Jordan (Author/Creator) - New South Wales Department of Primary IndustriesK.A. Worthing (Author/Creator) - The University of SydneyJ.M. Norris (Author/Creator) - The University of SydneyH.S. Wong (Author/Creator) - Murdoch University, School of Medical, Molecular and Forensic SciencesR. Abraham (Author/Creator) - Murdoch UniversityD.J. Trott (Author/Creator) - The University of AdelaideS. Abraham (Author/Creator) - The University of Adelaide
- Publication Details
- PLOS ONE, Vol.12(4), e0176379
- Publisher
- Public Library of Science
- Identifiers
- 991005544404007891
- Copyright
- © 2017 Saputra et al
- Murdoch Affiliation
- Centre for Biosecurity and One Health; Antimicrobial Resistance and Infectious Disease Laboratory; School of Medical, Molecular and Forensic Sciences; School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Microbiology
- ESI research areas
- Plant & Animal Science