Journal article
Antimicrobial-resistant Bacteroides fragilis in Thailand and their inhibitory effect in vitro on the growth of Clostridioides difficile
Anaerobe, Vol.73, Art. 102505
2022
Abstract
Objectives
The aim of this study was to investigate antimicrobial-resistant Bacteroides fragilis in Thailand and possible effects of such strains on human health and disease.
Methods
Phenotypic antimicrobial susceptibility testing was performed on 17 clinical B. fragilis isolates. The genome of one isolate was sequenced and analysed to explore its resistance genotype. An in vitro growth assay was conducted to evaluate the inhibitory effect of B. fragilis on Clostridioides difficile.
Results
There was a high prevalence of clindamycin (71%), meropenem (47%) and moxifloxacin (29%) resistance. Most strains remained susceptible to metronidazole, but one had high-level metronidazole resistance conferred by a nimD-containing plasmid. B. fragilis displayed an in vitro inhibitory effect on the growth of C. difficile and a drug-resistant strain retained this inhibition in the presence of clindamycin.
Conclusions
Antimicrobial resistance was seen in Thai B. fragils isolates, which may help protect the host against C. difficile infection.
Details
- Title
- Antimicrobial-resistant Bacteroides fragilis in Thailand and their inhibitory effect in vitro on the growth of Clostridioides difficile
- Authors/Creators
- K. Imwattana (Author/Creator) - The University of Western AustraliaP. Kiratisin (Author/Creator) - Siriraj HospitalT.V. Riley (Author/Creator) - The University of Western Australia
- Publication Details
- Anaerobe, Vol.73, Art. 102505
- Publisher
- Academic Press
- Identifiers
- 991005541158807891
- Copyright
- © 2022 Elsevier Ltd.
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.422 Antibiotic Pharmacokinetics
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology