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Journal article
Antimicrobial surveillance: A 20-year history of the SMART approach to addressing global antimicrobial resistance into the future
International Journal of Antimicrobial Agents, Vol.62(6), 107014
2023
Abstract
Antimicrobial resistance (AMR) is a major global public health threat, particularly affecting patients in resource-poor settings. Comprehensive surveillance programs are essential to reducing the high mortality and morbidity associated with AMR and integral to informing treatment decisions and guidelines, appraising effectiveness of intervention strategies, and directing development of new antibacterial agents. Various surveillance programs exist worldwide, including those administered by government bodies or funded by the pharmaceutical industry. One of the largest and longest-running industry-sponsored AMR surveillance programs is the Study for Monitoring Antimicrobial Resistance Trends (SMART), which recently completed its 20th year. The SMART database has grown to almost 500,000 isolates from over 200 sites in more than 60 countries, encompassing all major geographic regions and including many sites in low- and middle-income countries. The SMART surveillance program has evolved in scope over time, including additional antibacterial agents, pathogens, and infection sites in line with changing epidemiology and medical need. Surveillance data from SMART and similar programs have been used successfully to detect emerging resistance threats and AMR patterns in specific countries and regions, thus informing national and local clinical treatment guidelines. The SMART database can be accessed readily by physicians and researchers globally, which may be especially valuable to those from countries with limited health care resources, where surveillance and resistance data are rarely collected. Continued participation from as many sites as possible worldwide and maintenance of adequate funding are critical factors to fully realizing the potential of large-scale AMR surveillance programs into the future.
Details
- Title
- Antimicrobial surveillance: A 20-year history of the SMART approach to addressing global antimicrobial resistance into the future
- Authors/Creators
- Rafael Cantón - Instituto de Salud Carlos IIIThomas Gottlieb - Concord Repatriation General HospitalGeoffrey W. Coombs - Murdoch UniversityPatrick C.Y. Woo - National Chung Hsing UniversityTony M. Korman - Fiona Stanley HospitalMaria Garcia-Castillo - Instituto Ramón y Cajal de Investigación SanitariaDenise Daley - Fiona Stanley HospitalKarri A. Bauer - Merck & Co., Inc., Rahway, NJ, USA (United States)Michael Wong - Merck & Co., Inc., Rahway, NJ, USA (United States)Dominik J. Wolf - Merck & Co., Inc., Rahway, NJ, USA (United States)Fakhar Siddiqui - Merck & Co., Inc., Rahway, NJ, USA (United States)Mary Motyl - Merck & Co., Inc., Rahway, NJ, USA (United States)
- Publication Details
- International Journal of Antimicrobial Agents, Vol.62(6), 107014
- Publisher
- Elsevier Ltd. on behalf of International Society of Chemotherapy and Elsevier Ltd.
- Identifiers
- 991005609283907891
- Copyright
- © 2023 Merck Sharp & Dohme LLC., a subsidiary of Merck & Co., Inc. © 2023 The Author(s).
- Murdoch Affiliation
- Centre for Biosecurity and One Health
- Language
- English
- Resource Type
- Journal article
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