Journal article
Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie–Boulder, Western Australia
Pathology, Vol.42(3), pp.273-279
2010
Abstract
Aim: To investigate antimicrobial susceptibility of Moraxella catarrhalis isolated from a cohort of children being followed in a study of the natural history of otitis media in a semi-arid region of Western Australia.
Methods: In the Kalgoorlie Otitis Media Research Project nasopharyngeal aspirates were collected from children up to seven times between the age of 1 week and 2 years. A total of 261 M. catarrhalis strains from 50 Aboriginal and 50 non-Aboriginal children were tested against 14 antibiotics using the Clinical and Laboratory Standards Institute (CLSI) agar dilution method.
Results: All strains were susceptible to amoxicillin/clavulanate, cefuroxime, azithromycin, ciprofloxacin, moxifloxacin, levofloxacin, erythromycin and minocycline. While no criteria exist for assessment of susceptibility to roxithromycin, minimum inhibitory concentrations (MICs) were low. Approximately 46% of strains from Aboriginal children and 27% from non-Aboriginal children appeared susceptible to ampicillin. A small number of strains was intermediately resistant to cefaclor (9/261, 3.4%), while the bulk of strains was intermediately resistant to co-trimoxazole. A low prevalence of tetracycline resistance (3/261, 1.1%) was noted. β-lactamase production was observed in 97.7% of strains.
Conclusions: While M. catarrhalis strains from children of the Kalgoorlie region were susceptible to many of the antibiotics used to treat respiratory tract infections, a large proportion of strains were resistant to ampicillin and/or co-trimoxazole. Current therapeutic guidelines, which recommend amoxicillin for treatment of otitis media, may need to be revised.
Details
- Title
- Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie–Boulder, Western Australia
- Authors/Creators
- N.M. Pingault (Author/Creator) - The University of Western AustraliaJ.M. Bowman (Author/Creator) - Pathwest Laboratory MedicineD. Lehmann (Author/Creator) - The Kids Research Institute AustraliaT.V. Riley (Author/Creator) - The University of Western Australia
- Publication Details
- Pathology, Vol.42(3), pp.273-279
- Publisher
- Elsevier
- Identifiers
- 991005544484707891
- Copyright
- © 2010 Royal College of Pathologists of Australasia
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1.23 Antibiotics & Antimicrobials
- 1.23.347 Streptococcus Pneumoniae
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