Journal article
Antisense oligonucleotides targeting angiogenic factors as potential cancer therapeutics
Molecular Therapy - Nucleic Acids, Vol.14(1), pp.142-157
2018
Abstract
Cancer is one of the leading causes of death worldwide and conventional cancer therapies such as surgery, chemotherapy and radiotherapy do not address the underlying molecular pathologies, leading to inadequate treatment and tumour recurrence. Angiogenic factors, such as EGF, PDGF, bFGF, TGF-β, TGF-α, VEGF, Endoglin and Angiopoietins play important roles in regulating tumour development and metastasis, and serve as potential targets for developing cancer therapeutics. Nucleic acid-based therapeutic strategies have received significant attention in the last two decades, and antisense oligonucleotide-mediated intervention is a prominent therapeutic approach for targeted manipulation of gene expression. Clinical benefits of antisense oligonucleotides have been recognised by the US Food and Drug Administration, with full or conditional approval of Vitravene, Kynamro, Exondys51 and Spinraza. Herein, we review the scope of antisense oligonucleotides that target angiogenic factors towards tackling solid cancers.
Details
- Title
- Antisense oligonucleotides targeting angiogenic factors as potential cancer therapeutics
- Authors/Creators
- B.T. Le (Author/Creator) - Murdoch UniversityP. Raguraman (Author/Creator) - Perron Institute for Neurological and Translational ScienceT.R. Kosbar (Author/Creator) - Murdoch UniversityS. Fletcher (Author/Creator) - Murdoch UniversityS.D. Wilton (Author/Creator) - Murdoch UniversityR.N. Veedu (Author/Creator) - Murdoch University
- Publication Details
- Molecular Therapy - Nucleic Acids, Vol.14(1), pp.142-157
- Publisher
- Cell Press
- Identifiers
- 991005541412307891
- Copyright
- © 2018 The Author(s)
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.988 Oligonucleotide Modifications
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Biology & Biochemistry