Journal article
Apolipoprotein E controls the risk and age at onset of Parkinson disease
Neurology, Vol.62(11), pp.2005-2009
2004
Abstract
Background: Similarities between Alzheimer disease (AD) and Parkinson disease (PD) suggest a possible role for apolipoprotein E (APOE) in PD. Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent.
Objective: To investigate APOE’s role in PD using family-based association analyses.
Methods: APOE functional polymorphisms were genotyped for 658 PD affected families, including 282 multiplex and 376 singleton families. The pedigree disequilibrium test (PDT) and the genotype-PDT were used to test the risk effect of APOE. The Monks-Kaplan test was used to evaluate the effect of APOE on age at onset of PD.
Results: APOE was significantly associated with risk of developing PD. Stratified analysis revealed that APOE was most strongly associated with families with a positive PD family history (global p = 0.003). Like AD, the APOE-4 allele increases disease risk while the APOE-3 allele decreases risk. We detected a positive association of APOE-3 (p = 0.019) and a negative association of APOE-4 (p = 0.015) with age at onset in PD.
Conclusions: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.
Details
- Title
- Apolipoprotein E controls the risk and age at onset of Parkinson disease
- Authors/Creators
- Y.J. Li (Author/Creator)M.A. Hauser (Author/Creator)W.K. Scott (Author/Creator)E.R. Martin (Author/Creator)M.W. Booze (Author/Creator)X.J. Qin (Author/Creator)J.W. Walter (Author/Creator)M.A. Nance (Author/Creator)J.P. Hubble (Author/Creator)W.C. Koller (Author/Creator)R. Pahwa (Author/Creator)M.B. Stern (Author/Creator)B.C. Hiner (Author/Creator)J. Jankovic (Author/Creator)C.G. Goetz (Author/Creator)G.W. Small (Author/Creator)F. Mastaglia (Author/Creator)J.L. Haines (Author/Creator)M.A. Pericak-Vance (Author/Creator)J.M. Vance (Author/Creator)
- Publication Details
- Neurology, Vol.62(11), pp.2005-2009
- Publisher
- American Academy of Neurology
- Identifiers
- 991005540700507891
- Copyright
- © 2004 American Academy of Neurology
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior