Apolipoprotein E ϵ4 in inclusion body myositis

M.J. Garlepp; H. Tabarias; F.M. van Bockxmeer; P.J. Zilko; B. Laing; F.L. Mastaglia

doi:10.1002/ana.410380619

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Apolipoprotein E ϵ4 in inclusion body myositis

Journal article

Peer reviewed

Apolipoprotein E ϵ4 in inclusion body myositis

M.J. Garlepp, H. Tabarias, F.M. van Bockxmeer, P.J. Zilko, B. Laing and F.L. Mastaglia

Annals of Neurolog, Vol.38(6), pp.957-959

1995

DOI: https://doi.org/10.1002/ana.410380619

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Abstract

The genetic predisposition to inclusion body myositis (IBM) is probably multifactorial. The deposition of the β-amyloid protein is a characteristic histological feature of both IBM and Alzheimer's disease (AD). The ϵ4 allele of apolipoprotein E (APO E) has been strongly associated with familial and late-onset AD. We therefore compared the APO E allele frequencies in a group of 14 patients with IBM with those in a group of patients with other inflammatory muscle diseases and in the general population. The frequency of the ϵ4 allele in IBM was increased (0.29) compared with that in patients with other inflammatory muscle diseases (0.15) and the general population (0.13) (p < 0.05). These data suggest that APO E genotype may be one of the factors involved in determining the predisposition to the development of IBM.

Details

Title: Apolipoprotein E ϵ4 in inclusion body myositis
Authors/Creators: M.J. Garlepp (Author/Creator) - Australian Neuromuscular Research Institute, Australia.
H. Tabarias (Author/Creator) - The University of Western Australia
F.M. van Bockxmeer (Author/Creator) - Royal Perth Hospital
P.J. Zilko (Author/Creator) - The University of Western Australia
B. Laing (Author/Creator) - The University of Western Australia
F.L. Mastaglia (Author/Creator) - Centre for Neuromuscular and Neurological Disorders
Publication Details: Annals of Neurolog, Vol.38(6), pp.957-959
Publisher: Wiley
Identifiers: 991005544673907891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Mechanisms
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior