Apolipoprotein ε alleles in sporadic inclusion body myositis: A reappraisal

M. Needham; A. Hooper; I. James; F. van Bockxmeer; A. Corbett; T. Day; M.J. Garlepp; F.L. Mastaglia

doi:10.1016/j.nmd.2007.09.005

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Apolipoprotein ε alleles in sporadic inclusion body myositis: A reappraisal

Journal article

Peer reviewed

Apolipoprotein ε alleles in sporadic inclusion body myositis: A reappraisal

M. Needham, A. Hooper, I. James, F. van Bockxmeer, A. Corbett, T. Day, M.J. Garlepp and F.L. Mastaglia

Neuromuscular Disorders, Vol.18(2), pp.150-152

2008

DOI: https://doi.org/10.1016/j.nmd.2007.09.005

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Abstract

Previous studies have differed as to whether APOE ε4 is a susceptibility factor for developing sporadic inclusion body myositis (sIBM), with a positive association being found only in an Australian cohort of cases. We have now re-examined this in a larger cohort of 57 sIBM cases and have also carried out a meta-analysis of all the published studies looking for evidence of a risk association or effect of APOEalleles on disease expression. Our findings argue against a specific role for any APOEalleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the ε2allele.

Details

Title: Apolipoprotein ε alleles in sporadic inclusion body myositis: A reappraisal
Authors/Creators: M. Needham (Author/Creator) - Queen Elizabeth II Medical Centre
A. Hooper (Author/Creator) - Royal Perth Hospital
I. James (Author/Creator) - Royal Perth Hospital
F. van Bockxmeer (Author/Creator) - Royal Perth Hospital
A. Corbett (Author/Creator) - Concord Repatriation General Hospital
T. Day (Author/Creator) - The Royal Melbourne Hospital
M.J. Garlepp (Author/Creator) - Curtin University
F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
Publication Details: Neuromuscular Disorders, Vol.18(2), pp.150-152
Publisher: Elsevier BV
Identifiers: 991005542622007891
Copyright: 2007 Elsevier BV
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1684 Dermatomyositis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior