Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions

J.H. Karnes; M.A. Miller; K.D. White; K.C. Konvinse; R.K. Pavlos; A.J. Redwood; J.G. Peter; R. Lehloenya; S.A. Mallal; E.J. Phillips

doi:10.1146/annurev-pharmtox-010818-021818

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Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions

Journal article

Peer reviewed

Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions

J.H. Karnes, M.A. Miller, K.D. White, K.C. Konvinse, R.K. Pavlos, A.J. Redwood, J.G. Peter, R. Lehloenya, S.A. Mallal and E.J. Phillips

Annual Review of Pharmacology and Toxicology, Vol.59(1), pp.463-486

2019

DOI: https://doi.org/10.1146/annurev-pharmtox-010818-021818

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Abstract

Adverse drug reactions (ADRs) are a significant health care burden. Immunemediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but contribute a disproportionately high amount of that burden due to their severity. Variation in human leukocyte antigen (HLA) genes has emerged as a potential preprescription screening strategy for the prevention of previously unpredictable IM-ADRs. Immunopharmacogenomics combines the disciplines of immunogenomics and pharmacogenomics and focuses on the effects of immune-specific variation on drug disposition and IM-ADRs. In this review, we present the latest evidence for HLA associations with IM-ADRs, ongoing research into biological mechanisms of IM-ADRs, and the translation of clinical actionable biomarkers for IM-ADRs, with a focus on T cell-mediated ADRs.

Details

Title: Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions
Authors/Creators: J.H. Karnes (Author/Creator) - University of Arizona
M.A. Miller (Author/Creator) - University of Arizona
K.D. White (Author/Creator) - Vanderbilt University Medical Center
K.C. Konvinse (Author/Creator) - Vanderbilt University Medical Center
R.K. Pavlos (Author/Creator) - The Kids Research Institute Australia
A.J. Redwood (Author/Creator) - Murdoch University
J.G. Peter (Author/Creator) - University of Cape Town
R. Lehloenya (Author/Creator) - University of Cape Town
S.A. Mallal (Author/Creator) - Murdoch University
E.J. Phillips (Author/Creator) - Murdoch University
Publication Details: Annual Review of Pharmacology and Toxicology, Vol.59(1), pp.463-486
Publisher: Annual Reviews; Palo Alto, CA
Identifiers: 991005541451607891
Copyright: © 2019 by Annual Reviews
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.265 Dermatology - Skin Allergies; 1.265.1140 Drug Hypersensitivity
Web Of Science research areas: Pharmacology & Pharmacy; Toxicology
ESI research areas: Pharmacology & Toxicology