Journal article
Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo
Chemical Communications, Vol.49(37), pp.3836-3838
2013
Abstract
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
Details
- Title
- Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo
- Authors/Creators
- D.J. Coles (Author/Creator) - The University of QueenslandB.E. Rolfe (Author/Creator) - The University of QueenslandN.R.B. Boase (Author/Creator) - The University of QueenslandR.N. Veedu (Author/Creator) - The University of QueenslandK.J. Thurecht (Author/Creator) - The University of Queensland
- Publication Details
- Chemical Communications, Vol.49(37), pp.3836-3838
- Publisher
- Royal Society of Chemistry
- Identifiers
- 991005543699407891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 2 Chemistry
- 2.53 Polymers & Macromolecules
- 2.53.70 Nanocarrier Drug Delivery
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry