Are in vitro and in silico approaches used appropriately for animal-based major depressive disorder research?

Constanca Carvalho; Susana A. M. Varela; Tiago A. Marques; Andrew Knight; Luis Vicente

doi:10.1371/journal.pone.0233954

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Are in vitro and in silico approaches used appropriately for animal-based major depressive disorder research?

Journal article

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Are in vitro and in silico approaches used appropriately for animal-based major depressive disorder research?

Constanca Carvalho, Susana A. M. Varela, Tiago A. Marques, Andrew Knight and Luis Vicente

PloS one, Vol.15(6), e0233954

2020

DOI: https://doi.org/10.1371/journal.pone.0233954

PMID: 32579547

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Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

The current paradigm for biomedical research and drug testing postulates thatin vitroandin silicodata inform animal studies that will subsequently inform human studies. Recent evidence points out that animal studies have made a poor contribution to current knowledge of Major Depressive Disorder, whereas the contribution ofin vitroandin silicostudies to animal studies- within this research area- is yet to be properly quantified. This quantification is important since biomedical research and drug discovery and development includes two steps of knowledge transferability and we need to evaluate the effectiveness of both in order to properly implement 3R principles (Replacement, Reduction and Refinement). Here, we used the citation tracking facility within Web of Science to locate citations of original research papers onin vitroandin silicorelated to MDD published identified in PubMed by relevant search terms. 67 publications describing target papers were located. Bothin vitroandin silicopapers are more cited by human medical papers than by animal papers. The results suggest that, at least concerning MDD research, the current two steps of knowledge transferability are not being followed, indicating a poor compliance with the 3R principles.

Details

Title: Are in vitro and in silico approaches used appropriately for animal-based major depressive disorder research?
Authors/Creators: Constanca Carvalho - University of Lisbon
Susana A. M. Varela - University of Lisbon
Tiago A. Marques - University of St Andrews
Andrew Knight - University of Winchester
Luis Vicente - University of Lisbon
Publication Details: PloS one, Vol.15(6), e0233954
Publisher: Public Library of Science
Number of pages: 6
Grant note: Animalfree Research-Switzerland UID/MAT/00006/2019 / Centro de Estatistica e Aplicacoes (CEAUL) through Fundacao para a Ciencia e a Tecnologia, Portugal (FCT) UIDB/00678/2020 / Portuguese national funds within the Centro de Filosofia das Ciencia da Universidade de Lisboa (CFCUL) research center strategic project - Fundacao para a Ciencia e a Tecnologia (FCT)
Identifiers: 991005694576907891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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6 Times Cited - Web of Science

InCites Highlights

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.117 Pharmacology & Toxicology; 1.117.2161 Non-Animal Testing
Web Of Science research areas: Multidisciplinary Sciences
ESI research areas: Multidisciplinary