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Journal article
Arterial stiffness moderates the link between NfL and cognition: The IGNITE study
Alzheimer's & dementia, Vol.21(8), e70554
2025
PMID: 40775489
Abstract
INTRODUCTION
Arterial stiffness (carotid-femoral pulse wave velocity [cfPWV]) and plasma neurofilament light (NfL), markers of vascular and neuroaxonal aging, are linked to cognitive decline. Whether higher cfPWV amplifies the NfL–cognition relationship remains unclear.
METHODS
Cognitively unimpaired older adults (N = 570) were assessed using composite cognitive scores from confirmatory factor analysis. cfPWV was dichotomized at the median. Plasma NfL was quantified on a Single Moleculte Array-High Definition, model X (SIMOA-HD X).
RESULTS
Higher NfL correlated with poorer performance across all cognitive domains (p < 0.05), and higher cfPWV was linked to worse episodic memory, working memory, and processing speed (p < 0.05). NfL× cfPWV interactions were significant for episodic (β = 0.289, p = 0.048) and working memory (β = 0.287, p = 0.025), with stronger NfL–cognition associations in the higher cfPWV group (episodic memory: β = -0.324, p < 0.01; working memory: β = -0.343, p < 0.01).
DISCUSSION
Greater cfPWV amplified the association between NfL-related axonal degeneration and cognitive decline.
Details
- Title
- Arterial stiffness moderates the link between NfL and cognition: The IGNITE study
- Authors/Creators
- Amani M Norling - Hebrew SeniorLifeLewis A Lipsitz - Hebrew SeniorLifeAlyssa B Dufour - Hebrew SeniorLifeThomas G Travison - Hebrew SeniorLifeKelsey R Sewell - Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Western Australia, AustraliaAudrey M Collins - Translational Research Institute for Metabolism and DiabetesLu Wan - Translational Research Institute for Metabolism and DiabetesGeorge Grove - University of PittsburghHaiqing Huang - Translational Research Institute for Metabolism and DiabetesLauren E Oberlin - Weill Cornell MedicineShivangi Jain - Translational Research Institute for Metabolism and DiabetesThomas K Karikari - University of PittsburghJill K Morris - University of Kansas Medical CenterJohn M Jakicic - University of Kansas Medical CenterEdward McAuley - University of Illinois Urbana-ChampaignArthur F Kramer - Northeastern UniversityCharles H Hillman - Northeastern UniversityEric D Vidoni - University of Kansas Medical CenterSandra A Billinger - University of KansasJeffrey M Burns - University of KansasAnna L Marsland - University of PittsburghChaeryon Kang - University of PittsburghKirk I Erickson - University of Pittsburgh
- Publication Details
- Alzheimer's & dementia, Vol.21(8), e70554
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Grant note
- P30 AG072973 / NIA NIH HHS R01 AG083874 / NIA NIH HHS Professional Endowment from the Department of Psychiatry, University of Pittsburgh RF1 AG077474 / NIA NIH HHS UL1 TR002366 / NCATS NIH HHS P01 AG025204 / NIA NIH HHS R35 AG072307 to KIE / NIH/NIA R35 AG072307 / NIA NIH HHS R01 AG072641 / NIA NIH HHS HT94252320064 / U.S. Department of Defense
- Identifiers
- 991005806849507891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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