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Journal article
Assessment of antibacterial, nematicidal and herbicidal activities of Cautleya spicata (Sm.) Baker extracts, with chemical profiling using GC-MS
Scientific reports, Vol.15(1), 7179
2025
PMID: 40021776
Abstract
The pesticidal activity of the rhizome and aerial parts of Cautleya spicata (Sm.) Baker was investigated, revealing significant findings. The GC-MS analysis revealed significant compositional variability among the extracts. β-Sitosterol was identified as the dominant compound in all extracts prepared with hexane, acetone, and methanol, while α-humulene was prominently present in the rhizome extracts. The methanolic extracts of C. spicata demonstrated substantial nematicidal activity against Meloidogyne incognita and herbicidal activity against seeds of Raphanus raphanistrum subsp. Sativus (L.) (Radish) and Cichorium intybus L. (Chicory). Additionally, the extracts exhibited effective antibacterial activities against four bacterial strains, including Salmonella enterica serotype typhi, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus. In-silico molecular docking studies identified stigmasterol as exhibiting the best binding affinities with the studied proteins. These results highlight the potential of C. spicata extracts as promising candidates for the development of botanical pesticides and antibacterial agents.
Details
- Title
- Assessment of antibacterial, nematicidal and herbicidal activities of Cautleya spicata (Sm.) Baker extracts, with chemical profiling using GC-MS
- Authors/Creators
- Sonu Kumar Mahawer - Govind Ballabh Pant University of Agriculture and TechnologyHimani Karakoti - Govind Ballabh Pant University of Agriculture and TechnologyRavendra Kumar - Govind Ballabh Pant University of Agriculture and TechnologyOm Prakash - Govind Ballabh Pant University of Agriculture and TechnologySatya Kumar - Govind Ballabh Pant University of Agriculture and TechnologyShilpi Rawat - Govind Ballabh Pant University of Agriculture and TechnologyDharmendra Singh Rawat - Govind Ballabh Pant University of Agriculture and TechnologyPushpendra Koli - Indian Grassland and Fodder Research InstituteShivangi Chamoli - Graphic Era UniversityPiyush Kumar - University of Petroleum and Energy StudiesJolanta Maslowiecka - Bialystok, PolandValery A. Isidorov - Bialystok University of TechnologyYonglin Ren - Murdoch University, Centre for Biosecurity and One Health
- Publication Details
- Scientific reports, Vol.15(1), 7179
- Publisher
- Nature Publishing Group UK
- Number of pages
- 21
- Grant note
- Govind Ballabh Pant University of Agriculture and Technology
The authors acknowledge the Govind Ballabh Pant University of Agriculture and Technology for providing the necessary administrative and laboratory facilities for conducting the experiments.
- Identifiers
- 991005751329507891
- Copyright
- © The Author(s) 2025
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.275 Crop Protection
- 3.275.1891 Allelopathy
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Chemistry