Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals

G.R. Martin; R.J. Sutherland; I.D. Robertson; W.E. Kirkpatrick; D.R. King; P.J. Hood

doi:10.1111/j.1751-0813.1991.tb03217.x

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Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals

Journal article

Peer reviewed

Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals

G.R. Martin, R.J. Sutherland, I.D. Robertson, W.E. Kirkpatrick, D.R. King and P.J. Hood

Australian Veterinary Journal, Vol.68(7), pp.241-243

1991

DOI: https://doi.org/10.1111/j.1751-0813.1991.tb03217.x

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Abstract

The toxicity of pindone, a rabbit poison, to horses, cattle, goats, chickens, dogs and cats was investigated, using extension of prothrombin time (PT) as an index of poisoning. The daily dose of pindone, administered for 5 days, ranged from 0.3 mg/kg for dogs to 2.5 mg/kg for chickens. This range of dose rates was considered to be indicative of the worst possible case that could arise following a campaign of baiting for rabbits. Although significant elevations in PT (more than double baseline values) were noted in all species other than horses, clinical signs of anticoagulant poisoning were not observed in any of the species tested. From the observed PT, cattle and cats appeared to be the most susceptible, and horses the least susceptible, to pindone toxicity. The half-lives of the elevated PT were calculated as 3.1 days for cattle, 2.8 days for goats and chickens, 1.9 days for horses and dogs and less than one day for cats. It is proposed that these half-lives can be used as a guide for determining the duration of treatment of pindone-affected animals.

Details

Title: Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals
Authors/Creators: G.R. Martin (Author/Creator) - Agriculture Protection Board of Western Australia, Forrestfield.
R.J. Sutherland (Author/Creator) - Murdoch University
I.D. Robertson (Author/Creator) - Murdoch University
W.E. Kirkpatrick (Author/Creator) - Government of Western Australia
D.R. King (Author/Creator) - Government of Western Australia
P.J. Hood (Author/Creator) - Murdoch University
Publication Details: Australian Veterinary Journal, Vol.68(7), pp.241-243
Publisher: Wiley-Blackwell
Identifiers: 991005542688007891
Murdoch Affiliation: School of Veterinary Studies
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.94 Cardiac Arrhythmia; 1.94.1664 Warfarin and Vitamin K
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science