Journal article
Assessment of the respiratory actions of intramuscular morphine in conscious dogs
Research in Veterinary Science, Vol.67(2), pp.141-148
1999
Abstract
The actions on the respiratory system of 0.25, 0.5 and 1.0 mg kg -1 morphine given intramuscularly were studied in conscious dogs. Dogs breathed oxygen with 0, 2 and 4 per cent CO 2, in that order, through a mask attached to a flow sensor and connected to a respiratory mechanics monitor. When a steady state period of respiration was reached breathing pure oxygen, respiratory rate, tidal volume, respiratory minute volume, peak expiratory flow rate and end tidal CO 2 (PetCO 2) were measured. The respiratory minute volume and PetCO 2 were measured when the dogs breathed 2 and 4 per cent CO 2 in oxygen, the points plotted onto a graph and the gradient of the line, describing the PCO 2/ventilation response, plus the intercept with the y-axis were determined. Measurements for each morphine dose were taken before injection and at 30 minutes, 1, 2, 3, 4, 6 and 8 hours post injection. The incidence of panting after morphine was dose related and it occurred in all dogs given the high dose. Morphine reduced the gradients of the PCO 2/ventilation response lines and raised the intercept. Other changes were increased respiratory minute volume and peak expiratory flow and decreased PetCO 2 and tidal volume.
Details
- Title
- Assessment of the respiratory actions of intramuscular morphine in conscious dogs
- Authors/Creators
- L.K. Cullen (Author/Creator) - Murdoch UniversityM.R. Raffe (Author/Creator) - University of MinnesotaD.A. Randall (Author/Creator) - University of MinnesotaD.R. Bing (Author/Creator) - Children’s Minnesota - St. Paul Hospital
- Publication Details
- Research in Veterinary Science, Vol.67(2), pp.141-148
- Publisher
- Harcourt Publishers Ltd
- Identifiers
- 991005543707307891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.1642 Veterinary Anesthesia
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science