Association analysis of IL20RA and IL20RB genes in psoriasis

K. Kingo; R. Mössner; R. Rätsep; K. Raud; U. Krüger; H. Silm; E. Vasar; K. Reich; S. Kõks

doi:10.1038/gene.2008.36

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Association analysis of IL20RA and IL20RB genes in psoriasis

Journal article

Peer reviewed

Association analysis of IL20RA and IL20RB genes in psoriasis

K. Kingo, R. Mössner, R. Rätsep, K. Raud, U. Krüger, H. Silm, E. Vasar, K. Reich and S. Kõks

Genes & Immunity, Vol.9(5), pp.445-451

2008

DOI: https://doi.org/10.1038/gene.2008.36

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Abstract

The interleukin-20-receptor I complex (IL-20-RI) is composed of two chains, IL20RA and IL20RB. Its ligands are the three members of the IL19 subfamily of cytokines, IL-19, IL-20 and IL-24. These cytokines are important in the manifestation of psoriatic lesions and, recently, an association of polymorphisms of IL20 with psoriasis has been described. In the present study we tested the hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and investigated single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients (n=254) and healthy controls (n=224). We found no association of any of the investigated SNPs with the disease. Analysis of pairwise linkage disequilibrium (LD) across studied markers revealed a strong level of LD between SNPs within the IL20RA gene and SNPs within the IL20RB gene, and, for both genes six common haplotypes were identified with an estimated frequency ⩾1%. Haplotype analyses suggested that the IL20RA haplotype CCG (rs1184860, rs1167846, rs1167849) is significantly associated with psoriasis (OR 3.14, 95% CI 1.61–6.14), whereas the TTG haplotype had a protective effect (OR 0.20, 95% CI 0.07–0.55). The risk haplotype defining SNPs 1167846 and 1184860 were found to modify paired box 5 and homeobox A9 sites, respectively, two transcription factors related to the differentiation of immune cells. Further studies are needed to confirm the genetic association and to investigate the functional relevance of IL20RA haplotypes in psoriasis.

Details

Title: Association analysis of IL20RA and IL20RB genes in psoriasis
Authors/Creators: K. Kingo (Author/Creator) - University of Tartu
R. Mössner (Author/Creator) - University of Göttingen
R. Rätsep (Author/Creator) - University of Tartu
K. Raud (Author/Creator) - University of Tartu
U. Krüger (Author/Creator) - University of Göttingen
H. Silm (Author/Creator) - University of Tartu
E. Vasar (Author/Creator) - University of Tartu
K. Reich (Author/Creator) - Dermatologikum Hamburg
S. Kõks (Author/Creator) - University of Tartu
Publication Details: Genes & Immunity, Vol.9(5), pp.445-451
Publisher: Springer Nature
Identifiers: 991005543355407891
Copyright: © 2019 Springer Nature Limited
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.487 Regulatory T Cells
Web Of Science research areas: Genetics & Heredity; Immunology
ESI research areas: Molecular Biology & Genetics