Journal article
Association analysis of class II cytokine and receptor genes in vitiligo patients
Human Immunology, Vol.77(5), pp.375-381
2016
Abstract
The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regions of respective genes to be genotyped in Estonian case-control sample (109 and 328 individuals, respectively). For more precise analyses, patients were divided into subgroups based on vitiligo progression activity, age of onset, sex, occurrence of vitiligo among relatives, extent of depigmented areas, appearance of Köbner’s phenomenon, existence of halo nevi, occurrence of spontaneous repigmentation, and amount of thyroid peroxidase antibodies. No associations appeared in whole vitiligo group. In subgroups, several allelic and haplotype associations were found. The strongest involved SNPs rs12301088 (near IL26 gene), that was associated with familial vitiligo and existence of halo nevi, and rs2257167 (IFNAR1 gene), that was associated with female vitiligo. Additionally, haplotypes consisting of rs12301088 and rs12321603 alleles (IL26–IL22 genes), that were associated with familial vitiligo and existence of halo nevi. In conclusion, several genetic associations with vitiligo subphenotypes were revealed and functional explanations to these remain to be determined in respective studies.
Details
- Title
- Association analysis of class II cytokine and receptor genes in vitiligo patients
- Authors/Creators
- T. Traks (Author/Creator) - University of TartuM. Karelson (Author/Creator) - Tartu University HospitalE. Reimann (Author/Creator) - University of TartuR. Rätsep (Author/Creator) - University of TartuH. Silm (Author/Creator) - Tartu University HospitalE. Vasar (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuK. Kingo (Author/Creator) - Tartu University Hospital
- Publication Details
- Human Immunology, Vol.77(5), pp.375-381
- Publisher
- Elsevier BV
- Identifiers
- 991005540418107891
- Copyright
- © 2016 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.158 Dermatology - General
- 1.158.918 Melanogenesis Mechanisms
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology