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Journal article
Association between 24-h time-use composition and brain age: The IGNITE study
Alzheimer's & dementia : translational research & clinical interventions, Vol.11(4), e70187
2025
PMID: 41445670
Abstract
INTRODUCTION
The relationships between 24-h time-use composition (i.e., sleep, sedentary behavior, light physical activity, and moderate-to-vigorous physical activity [MVPA]) and brain morphology in older adulthood remain poorly understood. We examined associations between 24-h time-use composition and brain age using compositional data analysis, predicting that 24-h time use would be associated with brain age and that a greater amount of time engaged in MVPA would drive associations with younger brain age.
METHODS
Baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE; n = 648) were analyzed. Brain age was estimated using T1-weighted magnetic resonance imaging data. Time-use composition was derived from wrist-worn triaxial accelerometers. Regression models examined associations between 24-h time-use composition (expressed as isometric log ratios) and brain age, adjusting for age, sex, apolipoprotein E4 (APOE4) carriage, education, body mass index, image quality, and site. Compositional isotemporal substitution evaluated how hypothetical reallocations of time between behaviors related to brain age.
RESULTS
The final sample included 573 adults (69.8±3.7 years, 407 females). It was found that 24-h time-use composition was associated with brain age (F = 2.72, p = 0.004). Post hoc modeling indicated that time spent in MVPA primarily drove these associations, such that less MVPA was associated with greater brain age, irrespective of whether time was taken from sleep, sedentary behavior, or light physical activity.
DISCUSSION
These results suggest that 24-h time use, especially time spent in MVPA, relates to structural brain age in late adulthood. Maintaining or increasing MVPA may help preserve younger brain age, irrespective of which behaviors this time was reallocated from. Future research should examine whether systematically shifting 24-h time use toward MVPA alters brain aging trajectories.
Details
- Title
- Association between 24-h time-use composition and brain age: The IGNITE study
- Authors/Creators
- Audrey M. Collins - Translational Research Institute for Metabolism and DiabetesMaddison L. Mellow - Alliance for Research in Exercise, Nutrition and Activity (ARENA) Research Centre, Allied Health and Human Performance, University of South Australia, Adelaide, SA, AustraliaLu Wan - Translational Research Institute for Metabolism and DiabetesAshleigh E. Smith - Alliance for Research in Exercise, Nutrition and Activity (ARENA) Research Centre, Allied Health and Human Performance, University of South Australia, Adelaide, SA, AustraliaLauren E. Oberlin - Weill Cornell MedicineKelsey R. Sewell - Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, AustraliaNeha P. Gothe - Northeastern UniversityJason Fanning - Wake Forest UniversityJairo H. Migueles - Universidad de GranadaDorothea Dumuid - University of South AustraliaAaron Miatke - University of South AustraliaJohn M. Jakicic - University of Kansas Medical CenterChaeryon Kang - University of PittsburghGeorge Grove - University of PittsburghHaiqing Huang - Translational Research Institute for Metabolism and DiabetesBradley P. Sutton - University of Illinois Urbana-ChampaignAnna L. Marsland - University of PittsburghM. Ilyas Kamboh - University of PittsburghArthur F. Kramer - Northeastern UniversityEric D. Vidoni - University of Kansas Medical CenterCharles H. Hillman - Northeastern UniversityJeffrey M. Burns - University of KansasEdward McAuley - University of Illinois Urbana-ChampaignKirk I. Erickson - University of Pittsburgh
- Publication Details
- Alzheimer's & dementia : translational research & clinical interventions, Vol.11(4), e70187
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Grant note
- K23MH129882 / National Institute of Mental Health (100000025) Dementia Australia Research Foundation (100008710) R01 AG053952 / National Institutes of Health (100000002) DECRA DE230101174 / Australian Research Council (501100000923) R35 AG072307 / National Institutes of Health (100000002)
- Identifiers
- 991005848588707891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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