Journal article
Association between the σC protein of avian reovirus and virus-induced fusion of cells
Archives of Virology, Vol.144(1), pp.193-197
1999
Abstract
Monoclonal antibodies (MAbs) against a 39 kDa (σC) protein of the avian reovirus RAM-1 strain inhibited virus-induced fusion of cells and the protein was expressed on the surface of infected cells. The fusion-inhibiting activity of the three MAbs reacting with the σC protein suggest two putative epitopes were involved: one epitope recognised by antibody 6H1 and involved in fusion of both Vero and CK cells and a second epitope recognised by antibody 1G1 involved in fusion of Vero cells but not CK cells. The activity of the MAb 6E2 was intermediate, suggesting it may have been located in an intermediate position between the two putative epitopes and inhibited fusion by steric hindrance.
Details
- Title
- Association between the σC protein of avian reovirus and virus-induced fusion of cells
- Authors/Creators
- J. Meanger (Author/Creator)R. Wickramasinghe (Author/Creator)C.E. Enriquez (Author/Creator)G.E. Wilcox (Author/Creator)
- Publication Details
- Archives of Virology, Vol.144(1), pp.193-197
- Publisher
- Springer Verlag
- Identifiers
- 991005543814807891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.228 Virology - Tropical Diseases
- 1.228.1892 Arbovirus Dynamics
- Web Of Science research areas
- Virology
- ESI research areas
- Microbiology