Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis

David J Margolis; Nandita Mitra; Ole J Hoffstad; Ronald Berna; Brian S Kim; Abha Chopra; Elizabeth J Phillips

doi:10.1038/s41598-023-28847-y

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Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis

Journal article

Open access

Peer reviewed

Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis

David J Margolis, Nandita Mitra, Ole J Hoffstad, Ronald Berna, Brian S Kim, Abha Chopra and Elizabeth J Phillips

Scientific reports, Vol.13(1), 1730

2023

DOI: https://doi.org/10.1038/s41598-023-28847-y

PMID: 36720995

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Abstract

Alleles

Case-Control Studies

Dermatitis, Atopic - genetics

Genes, MHC Class I

Humans

Ligands

Receptors, KIR - genetics

Receptors, KIR2DL5 - genetics

Natural killer cells (NK) have been associated with the pathophysiology of atopic dermatitis (AD). NK function is regulated by killer cell Ig-like receptor family (KIR) receptors that interact with HLA ligands. The study goal was to focus on allelic variation in genes KIR2DL5, KIR2DS5, and KIR2DS1 with respect to AD. This was a case-control study of individuals with (n = 313) and without (n = 176) AD. Associations were estimated using logistic regression. The prevalence of KIR2DL5 was 52.5% (95% CI 48.0,57.0), KIR2DS5 was 33.0% (28.8,37.3), and KIR2DS1 was 33.6% (29.4,38.0). The presence of the KIR2DL5*001:01 increased the odds of having AD by about 86% (odds ratio (OR): 1.86(1.23,2.82) p = 0.003). The risk for individuals homozygous for KIR2DL5*001:01 was even greater (OR: 2.16 (95% CI 1.31,3.53) p = 0.0023). The odds of having AD with KIR2DL5*001:01 was similar in Whites and Blacks. Allelic variation in KIR2DS5 and KIR2DS1 was not associated with AD. There is no known HLA binding ligand for KIR2DL5. The effect of KIR2DL5*001:01 increased in the presence of HLA-B*-21TT leader sequence (2.46(1.37,4.41) p = 0.0025) and the HLA-C2 ligand (2.07 (1.37,4.41, p = 0.000002). Our study shows an independent association of the KIR2DL5*001:01 with AD and is the first study to associate AD with KIR allelic variation.

Details

Title: Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis
Authors/Creators: David J Margolis - University of Pennsylvania
Nandita Mitra - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Ole J Hoffstad - University of Pennsylvania
Ronald Berna - University of Pennsylvania
Brian S Kim - Icahn School of Medicine at Mount Sinai
Abha Chopra - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
Elizabeth J Phillips - Center for Drug Safety and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
Publication Details: Scientific reports, Vol.13(1), 1730
Publisher: Springer Nature
Grant note: P30 AR069589 / NIAMS NIH HHS P30 AR079200 / NIAMS NIH HHS R01 AR070873 / NIAMS NIH HHS R01 AG060962 / NIA NIH HHS
Identifiers: 991005593770207891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.1091 Atopic Dermatitis
Web Of Science research areas: Immunology
ESI research areas: Immunology