Journal article
Association of TGIFLX/Y mRNA expression with prostate cancer
Medical Oncology, Vol.26(1), pp.73-77
2009
Abstract
Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identified. TGIFLX/Y (TGIFLX and TGIFLY) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate TGIFLX/Y mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of TGIFLX/Y mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both TGIFLX and TGIFLY and a Gleason score of >or=6 (P = 0.038). By contrast, expression of TGIFLX/Y mRNA in BPH samples could not be detected. These results suggest an association of TGIFLX/Y expression with the progression of prostate cancer.
Details
- Title
- Association of TGIFLX/Y mRNA expression with prostate cancer
- Authors/Creators
- Z. Ousati Ashtiani (Author/Creator)M. Ayati (Author/Creator)M.H. Modarresi (Author/Creator)R. Raoofian (Author/Creator)B. Sabah Goulian (Author/Creator)W.K. Greene (Author/Creator)M. Heidari (Author/Creator)
- Publication Details
- Medical Oncology, Vol.26(1), pp.73-77
- Publisher
- Humana Press, Inc.
- Identifiers
- 991005543466307891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.108 Molecular & Cell Biology - Cancer & Development
- 1.108.207 Neural Crest
- Web Of Science research areas
- Oncology
- ESI research areas
- Clinical Medicine