Journal article
Association of cardiovascular factors and Alzheimer's disease plasma amyloid-β protein in subjective memory complainers
Journal of Alzheimer's disease : JAD, Vol.17(2), pp.305-318
2009
Abstract
A strong link is indicated between cardiovascular disease (CVD) and risk for developing Alzheimer's disease (AD), which may be exacerbated by the major AD genetic risk factor apolipoprotein Eε4 (APOEε4). Since subjective memory complaint (SMC) may potentially be an early indicator for cognitive decline, we examined CVD risk factors in a cohort of SMC. As amyloid-ε (Aβ) is considered to play a central role in AD, we hypothesized that the CVD risk profile (increased LDL, reduced HDL, and increased body fat) would be associated with plasma Aβ levels. We explored this in 198 individuals with and without SMC (average age = 63 years). Correlations between Aβ40 and HDL were observed, which were stronger in non-APOEε4 carriers (rho = −0.315, p < 0.001) and in SMC (rho = −0.322, p = 0.01). There was no relationship between percentage body fat and Aβ40 in this cohort. Age and HDL remained predictive for plasma Aβ40 using multivariate regression analysis. We report a novel negative association between HDL and Aβ, which if demonstrated to be causal has implications for the development of lifestyle interventions and/or novel therapeutics. The relationship between HDL and Aβ and the potential significance of such an association needs to be validated in a larger longitudinal study.
Details
- Title
- Association of cardiovascular factors and Alzheimer's disease plasma amyloid-β protein in subjective memory complainers
- Authors/Creators
- K.A. Bates (Author/Creator) - Edith Cowan UniversityH.R. Sohrabi (Author/Creator) - School of Psychiatry and Clinical NeurosciencesM. Rodrigues (Author/Creator) - Edith Cowan UniversityJ. Beilby (Author/Creator) - School of Pathology and Laboratory MedicineS.S. Dhaliwal (Author/Creator) - Curtin UniversityK. Taddei (Author/Creator) - Edith Cowan UniversityA. Criddle (Author/Creator) - Western Medicine, Hollywood Specialist Centre, Nedlands, WA, AustraliaM. Wraith (Author/Creator) - Western Medicine, Hollywood Specialist Centre, Nedlands, WA, AustraliaM. Howard (Author/Creator) - Edith Cowan UniversityG. Martins (Author/Creator) - Edith Cowan UniversityA. Paton (Author/Creator) - School of Psychiatry and Clinical NeurosciencesP. Mehta (Author/Creator) - New York State Office for People With Developmental DisabilitiesJ.K. Foster (Author/Creator) - School of Paediatrics and Child HealthI.J. Martins (Author/Creator) - School of Psychiatry and Clinical NeurosciencesN.T. Lautenschlager (Author/Creator) - School of Psychiatry and Clinical NeurosciencesF.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical CentreS.M. Laws (Author/Creator) - Technical University MunichS.E. Gandy (Author/Creator) - Icahn School of Medicine at Mount SinaiR.N. Martins (Author/Creator) - School of Psychiatry and Clinical Neurosciences
- Publication Details
- Journal of Alzheimer's disease : JAD, Vol.17(2), pp.305-318
- Publisher
- IOS Press
- Identifiers
- 991005544266207891
- Copyright
- © 2009 IOS Press
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior