Journal article
Association of limbic system-associated membrane protein (LSAMP) to male completed suicide
BMC Medical Genetics, Vol.9(1)
2008
Abstract
Background
Neuroimaging studies have demonstrated volumetric abnormalities in limbic structures of suicide victims. The morphological changes might be caused by some inherited neurodevelopmental defect, such as failure to form proper axonal connections due to genetically determined dysfunction of neurite guidance molecules. Limbic system-associated membrane protein (LSAMP) is a neuronal adhesive molecule, preferentially expressed in developing limbic system neuronal dendrites and somata. Some evidence for the association between LSAMP gene and behavior has come from both animal as well as human studies but further investigation is required. In current study, polymorphic loci in human LSAMP gene were examined in order to reveal any associations between genetic variation in LSAMP and suicidal behaviour.
Methods
DNA was obtained from 288 male suicide victims and 327 healthy male volunteers. Thirty SNPs from LSAMP gene and adjacent region were selected by Tagger algorithm implemented in Haploview 3.32. Genotyping was performed using the SNPlex™ (Applied Biosystems) platform. Data was analyzed by Genemapper 3.7, Haploview 3.32 and SPSS 13.0.
Results
Chi square test revealed four allelic variants (rs2918215, rs2918213, rs9874470 and rs4821129) located in the intronic region of the gene to be associated with suicide, major alleles being overrepresented in suicide group. However, the associations did not survive multiple correction test. Defining the haplotype blocks using confidence interval algorithm implemented in Haploview 3.32, we failed to detect any associated haplotypes.
Conclusion
Despite a considerable amount of investigation on the nature of suicidal behaviour, its aetiology and pathogenesis remain unknown. This study examined the variability in LSAMP gene in relation to completed suicide. Our results indicate that LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution.
Details
- Title
- Association of limbic system-associated membrane protein (LSAMP) to male completed suicide
- Authors/Creators
- A. Must (Author/Creator) - University of TartuG. Tasa (Author/Creator) - University of TartuA. Lang (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE. Maron (Author/Creator) - Tartu University HospitalM. Väli (Author/Creator) - University of Tartu
- Publication Details
- BMC Medical Genetics, Vol.9(1)
- Publisher
- BioMed Central
- Identifiers
- 991005544215107891
- Copyright
- © Must et al
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.108 Molecular & Cell Biology - Cancer & Development
- 1.108.1986 NCAM
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics