Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan

G.F. Gimalova; A.S. Karunas; Y.Y. Fedorova; E.R. Gumennaya; S.V. Levashova; Z.R. Khismatullina; E. Prans; S. Kõks; E.I. Etkina; E.K. Khusnutdinova

doi:10.1134/S002689331402006X

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Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan

Journal article

Peer reviewed

Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan

G.F. Gimalova, A.S. Karunas, Y.Y. Fedorova, E.R. Gumennaya, S.V. Levashova, Z.R. Khismatullina, E. Prans, S. Kõks, E.I. Etkina and E.K. Khusnutdinova

Molecular Biology, Vol.48(2), pp.227-237

2014

DOI: https://doi.org/10.1134/S002689331402006X

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Abstract

Atopic dermatitis is a common chronic inflammatory skin disease and depends on the interaction between environmental factors and genetic predisposition. A considerable role in allergic disorders is played by polymorphisms of the genes of pattern recognition receptors (PRRs), which recognize conserved standard molecular structures (patterns) unique to large pathogen groups. Polymorphisms of several PRR genes, including the genes of Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, and TLR10), NOD-like receptors (NOD1 and NOD2), and a lipopolysaccharide receptor (CD14) along with C11orf30 and LRRC32 from chromosome 11q13.5, were studied in atopic dermatitis patients and control subjects from Bashkortostan. TLR1 (rs5743571 and rs5743604), TLR6 (rs5743794), and TLR10 (rs11466617) polymorphisms were associated with atopic dermatitis. The results supported the idea that innate immunity and polymorphisms of the TLR2-family genes play a substantial role in atopic dermatitis.

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Title: Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan
Authors/Creators: G.F. Gimalova (Author/Creator) - Institute of Biochemistry and Genetics of Ufa Scientific Centre
A.S. Karunas (Author/Creator) - Bashkir State University
Y.Y. Fedorova (Author/Creator) - Institute of Biochemistry and Genetics of Ufa Scientific Centre
E.R. Gumennaya (Author/Creator) - Academy of Sciences of the Republic of Bashkortostan
S.V. Levashova (Author/Creator) - Bashkir State Medical University
Z.R. Khismatullina (Author/Creator) - Bashkir State Medical University
E. Prans (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
E.I. Etkina (Author/Creator) - Bashkir State Medical University
E.K. Khusnutdinova (Author/Creator) - Bashkir State University
Publication Details: Molecular Biology, Vol.48(2), pp.227-237
Publisher: Pleiades Publishing
Identifiers: 991005544487407891
Copyright: © 2014 Pleiades Publishing, Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.609 Toll-like Receptors
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Molecular Biology & Genetics