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Association of serum Cystatin C with neuromyelitis optica spectrum disorders
Journal article   Peer reviewed

Association of serum Cystatin C with neuromyelitis optica spectrum disorders

Y. Shu, L. Zhang, Y. Chang, R. Li, X. Sun, J. Li, H. Wu, Y. Yang, L. Peng, Z. Lu, …
European Journal of Neurology, Vol.25(7), pp.999-1002
2018
DOI: https://doi.org/10.1111/ene.13646
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Abstract

Background and purpose The relationship between Cystatin C (CysC) and neuromyelitis optica spectrum disorders (NMOSD) is unknown. Methods Serum CysC levels were measured in 105 Chinese patients with NMOSD (53 in relapse, 52 in remission) and 109 healthy controls (HCs). The association of CysC with NMOSD and its clinical and magnetic resonance imaging parameters were evaluated. Results Cystatin C levels were significantly lower in patients with relapsing NMOSD than in those in remission (P < 0.001) or HCs (P < 0.05). CysC levels in NMOSD remission were higher than in HCs (P = 0.002). CysC levels were positively associated with age and negatively associated with brain lesion numbers in relapsing NMOSD (r = −0.252, P = 0.069). Conclusion Our results indicate a reduced serum level of CysC in patients with relapsing NMOSD and an increased level in remission. Further studies on the role of CysC in NMOSD are warranted.

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Citation topics
1 Clinical & Life Sciences
1.203 Neuromuscular Disorders
1.203.147 Multiple Sclerosis
Web Of Science research areas
Clinical Neurology
Neurosciences
ESI research areas
Neuroscience & Behavior
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