Journal article
Association of von Willebrand factor blood levels with exercise hypertension
European Journal of Applied Physiology, Vol.115(5), pp.1057-1065
2015
Abstract
Purpose
A hypertensive response to moderate intensity exercise (HRE) is associated with increased cardiovascular risk. The mechanisms of an HRE are unclear, although previous studies suggest this may be due to haemostatic and/or haemodynamic factors. We investigated the relationships between an HRE with haemostatic and hemodynamic indices.
Methods
Sixty-four participants (57 ± 10 years, 71 % male) with indication for exercise stress testing underwent cardiovascular assessment at rest and during moderate intensity exercise, from which 20 participants developed an HRE (defined as moderate exercise systolic BP ≥170 mmHg/men and ≥160 mmHg/women). Rest, exercise and post-exercise blood samples were analysed for haemostatic markers, including von Willebrand factor (vWf), and haemodynamic measures of brachial and central blood pressure (BP), aortic stiffness and systemic vascular resistance index (SVRi).
Results
HRE participants had higher rest vWf compared with normotensive response to exercise (NRE) participants (1,927 mU/mL, 95 % CI 1,240–2,615, vs. 1,129 mU/mL, 95 % CI 871–1,386; p = 0.016). vWf levels significantly decreased from rest to post-exercise in HRE participants (p = 0.005), whereas vWf levels significantly increased from rest to exercise in NRE participants (p = 0.030). HRE participants also had increased triglycerides, rest BP, aortic stiffness and exercise SVRi (p < 0.05 for all). Rest vWf predicted exercise brachial systolic BP (β = 0.220, p = 0.043; adjusted R 2 = 0.451, p < 0.001) independent of age, sex, body mass index, triglycerides, rest brachial systolic BP and aortic stiffness.
Conclusions
Increased rest blood levels of vWf are independently associated with moderate intensity exercise systolic BP. These findings implicate abnormalities in haemostasis as a possible factor contributing to HRE at moderate intensity.
Details
- Title
- Association of von Willebrand factor blood levels with exercise hypertension
- Authors/Creators
- S.B. Nikolic (Author/Creator)M.J. Adams (Author/Creator)P. Otahal (Author/Creator)L.M. Edwards (Author/Creator)J.E. Sharman (Author/Creator)
- Publication Details
- European Journal of Applied Physiology, Vol.115(5), pp.1057-1065
- Publisher
- Springer Berlin Heidelberg
- Identifiers
- 991005540190907891
- Copyright
- © Springer-Verlag Berlin Heidelberg 2014
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.197 Hypertension Management
- Web Of Science research areas
- Physiology
- Sport Sciences
- ESI research areas
- Clinical Medicine