Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

S. Gaudieri; D. Nolan; E. McKinnon; C.S. Witt; S. Mallal; F.T. Christiansen

doi:10.1016/j.molimm.2004.07.041

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Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Journal article

Peer reviewed

Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

S. Gaudieri, D. Nolan, E. McKinnon, C.S. Witt, S. Mallal and F.T. Christiansen

Molecular Immunology, Vol.42(4), pp.557-560

2005

DOI: https://doi.org/10.1016/j.molimm.2004.07.041

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Abstract

The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens.

Details

Title: Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses
Authors/Creators: S. Gaudieri (Author/Creator) - Royal Perth Hospital
D. Nolan (Author/Creator) - Royal Perth Hospital
E. McKinnon (Author/Creator) - Royal Perth Hospital
C.S. Witt (Author/Creator) - Royal Perth Hospital
S. Mallal (Author/Creator) - Royal Perth Hospital
F.T. Christiansen (Author/Creator) - Royal Perth Hospital
Publication Details: Molecular Immunology, Vol.42(4), pp.557-560
Publisher: Pergamon Press
Identifiers: 991005541568007891
Copyright: © 2004 Published by Elsevier Ltd
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.1021 Natural Killer Cells
Web Of Science research areas: Biochemistry & Molecular Biology; Immunology
ESI research areas: Immunology