Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder

K. Koido; T. Traks; R. Balõtšev; T. Eller; A. Must; S. Kõks; E. Maron; I. Tõru; J. Shlik; V. Vasar; E. Vasar

doi:10.1038/tp.2012.74

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Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder

Journal article

Open access

Peer reviewed

Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder

K. Koido, T. Traks, R. Balõtšev, T. Eller, A. Must, S. Kõks, E. Maron, I. Tõru, J. Shlik, V. Vasar, …

Translational Psychiatry, Vol.2(8), pp.e152-e152

2012

DOI: https://doi.org/10.1038/tp.2012.74

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Abstract

The purpose of this case–control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed in 591 unrelated patients with the diagnoses of major depressive disorder (MDD) or panic disorder (PD) and in 384 healthy control subjects. The results showed a strong association between LSAMP SNPs and MDD, and a suggestive association between LSAMP SNPs and PD. This is the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.

Details

Title: Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
Authors/Creators: K. Koido (Author/Creator) - University of Tartu
T. Traks (Author/Creator) - University of Tartu
R. Balõtšev (Author/Creator) - University of Tartu
T. Eller (Author/Creator) - University of Tartu
A. Must (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
E. Maron (Author/Creator) - Imperial College London
I. Tõru (Author/Creator) - University of Tartu
J. Shlik (Author/Creator) - University of Ottawa
V. Vasar (Author/Creator) - University of Tartu
E. Vasar (Author/Creator) - University of Tartu
Publication Details: Translational Psychiatry, Vol.2(8), pp.e152-e152
Publisher: Macmillan Publishers Limited
Identifiers: 991005546333407891
Copyright: 2012 Macmillan Publishers Limited
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.108 Molecular & Cell Biology - Cancer & Development; 1.108.1986 NCAM
Web Of Science research areas: Psychiatry
ESI research areas: Psychiatry/Psychology