Journal article
Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine
The Journal of Infectious Diseases, Vol.185(1), pp.114-117
2002
Abstract
Influenza remains a major cause of morbidity and mortality, particularly in at-risk groups where vaccination reduces complications of infection but is not universally protective. In order to determine whether human leukocyte antigen (HLA) class II polymorphisms modulate anti-influenza antibody responses to vaccination, a cohort of HLA-typed at-risk donors was investigated. The subjects were recruited from a single urban family practice. Hemagglutination-inhibition (HAI) titers were measured immediately before and 28 days after subunit vaccination. Nonresponsiveness was defined as failure to mount an HAI response to any component of the trivalent influenza vaccine. When the nonresponders and responders with HLA class II were compared, the nonresponder group had more HLA-DRB1*07–positive donors (13/32 vs. 6/41 responders; P=.016, Fisher’s exact test) and fewer HLA-DQB1*0603-9/14–positive donors (2/32 vs. 14/41 responders; P=.0045). Thus, polymorphisms in HLA class II molecules appear to modulate antibody responses to influenza vaccination.
Details
- Title
- Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine
- Authors/Creators
- C.M. Gelder (Author/Creator)R. Lambkin (Author/Creator)K.W. Hart (Author/Creator)D. Fleming (Author/Creator)O.M. Williams (Author/Creator)M. Bunce (Author/Creator)K.I. Welsh (Author/Creator)S.E. Marshall (Author/Creator)J. Oxford (Author/Creator)
- Publication Details
- The Journal of Infectious Diseases, Vol.185(1), pp.114-117
- Publisher
- Oxford University Press
- Identifiers
- 991005542553507891
- Copyright
- 2002 Infectious Diseases Society of America
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.126 Influenza
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Immunology