Journal article
Associations of dietary protein and fiber intake with brain and blood amyloid-β
Journal of Alzheimer's disease : JAD, Vol.61(4), pp.1589-1598
2018
Abstract
Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer’s disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-β (Aβ). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain Aβ burden (n = 541, and n = 162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of ‘high’ brain Aβ burden (PiB PET SUVR≥1.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile (p = 0.008; p = 0.013). Thus, in this cohort, the more protein consumed, the less likelihood of ‘high’ Aβ burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain Aβ burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.
Details
- Title
- Associations of dietary protein and fiber intake with brain and blood amyloid-β
- Authors/Creators
- W.M.A.D.B. Fernando (Author/Creator) - Edith Cowan UniversityS.R. Rainey-Smith (Author/Creator)S.L. Gardener (Author/Creator) - Edith Cowan UniversityV.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS.C. Burnham (Author/Creator) - CSIRO Health and BiosecurityS.L. Macaulay (Author/Creator) - CSIRO Health and BiosecurityB.M. Brown (Author/Creator) - Murdoch UniversityV.B. Gupta (Author/Creator) - Edith Cowan UniversityH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityM. Weinborn (Author/Creator) - The University of Western AustraliaK. Taddei (Author/Creator) - Edith Cowan UniversityS.M. Laws (Author/Creator) - Edith Cowan UniversityK. Goozee (Author/Creator) - The University of Western AustraliaD. Ames (Author/Creator) - St Vincent's HealthC. Fowler (Author/Creator) - Florey Institute of Neuroscience and Mental HealthP. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthO. Salvado (Author/Creator) - CSIRO Health and BiosecurityC.C. Rowe (Author/Creator) - Austin HealthR.N. Martins (Author/Creator) - Edith Cowan University
- Publication Details
- Journal of Alzheimer's disease : JAD, Vol.61(4), pp.1589-1598
- Publisher
- IOS Press
- Identifiers
- 991005540839407891
- Copyright
- © IOS Press
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior