Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

S. Trend; J. Leffler; A.P. Jones; L. Cha; S. Gorman; D.A. Brown; S.N. Breit; A.G. Kermode; M.A. French; N.C. Ward; P.H. Hart

doi:10.1038/s41598-021-84881-8

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Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

Journal article

Open access

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Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

S. Trend, J. Leffler, A.P. Jones, L. Cha, S. Gorman, D.A. Brown, S.N. Breit, A.G. Kermode, M.A. French, N.C. Ward, …

Scientific Reports, Vol.11(1), Art. 5244

2021

DOI: https://doi.org/10.1038/s41598-021-84881-8

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Abstract

Altered composition of gut bacteria and changes to the production of their bioactive metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of multiple sclerosis (MS). However, the immunomodulatory actions of SCFAs and intermediaries in their ability to influence MS pathogenesis are uncertain. In this study, levels of serum SCFAs were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome (CIS; an early form of MS) or MS and compared to healthy controls. There was a small but significant reduction in propionate levels in the serum of patients with CIS or MS compared with healthy controls. The frequencies of circulating T follicular regulatory cells and T follicular helper cells were significantly positively correlated with serum levels of propionate. Levels of butyrate associated positively with frequencies of IL-10-producing B-cells and negatively with frequencies of class-switched memory B-cells. TNF production by polyclonally-activated B-cells correlated negatively with acetate levels. Levels of serum SCFAs associated with changes in circulating immune cells and biomarkers implicated in the development of MS.

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Title: Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
Authors/Creators: S. Trend (Author/Creator) - The Kids Research Institute Australia
J. Leffler (Author/Creator) - The Kids Research Institute Australia
A.P. Jones (Author/Creator) - The Kids Research Institute Australia
L. Cha (Author/Creator) - The Kids Research Institute Australia
S. Gorman (Author/Creator) - The Kids Research Institute Australia
D.A. Brown (Author/Creator) - Westmead Institute for Medical Research
S.N. Breit (Author/Creator) - St Vincent's Health
A.G. Kermode (Author/Creator) - Perron Institute for Neurological and Translational Science
M.A. French (Author/Creator) - The University of Western Australia
N.C. Ward (Author/Creator) - The University of Western Australia
P.H. Hart (Author/Creator) - The Kids Research Institute Australia
Publication Details: Scientific Reports, Vol.11(1), Art. 5244
Publisher: Springer Nature
Identifiers: 991005545553207891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.384 Gut Microbiota
Web Of Science research areas: Immunology
ESI research areas: Immunology