Journal article
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
Nature Communications, Vol.12, Article number: 721
2021
Abstract
Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.
Details
- Title
- Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
- Authors/Creators
- J.M. Roe (Author/Creator) - University of OsloD. Vidal-Piñeiro (Author/Creator) - University of OsloØ. Sørensen (Author/Creator) - University of OsloA.M. Brandmaier (Author/Creator) - Max Planck Institute for Human DevelopmentS. Düzel (Author/Creator) - Max Planck Institute for Human DevelopmentH.A. Gonzalez (Author/Creator) - The University of Texas at DallasR.A. Kievit (Author/Creator) - MRC Cognition and Brain Sciences UnitE. Knights (Author/Creator) - MRC Cognition and Brain Sciences UnitS. Kühn (Author/Creator) - Max Planck Institute for Human DevelopmentU. Lindenberger (Author/Creator) - University Medical Center Hamburg-EppendorfA.M. Mowinckel (Author/Creator) - University of OsloL. Nyberg (Author/Creator) - Umeå UniversityD.C. Park (Author/Creator) - The University of Texas at DallasS. Pudas (Author/Creator) - Umeå UniversityM.M. Rundle (Author/Creator) - The University of Texas at DallasK.B. Walhovd (Author/Creator) - University of OsloA.M. Fjell (Author/Creator) - University of OsloR. Westerhausen (Author/Creator) - University of OsloB. Brown (Author/Creator)
- Publication Details
- Nature Communications, Vol.12, Article number: 721
- Publisher
- Springer Nature
- Identifiers
- 991005540097407891
- Copyright
- © 2021 The Authors
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
- Additional Information
- Belinda Brown appears courtesy of The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.113 Brain Imaging
- 1.113.460 Advanced Neuroimaging
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior