Journal article
Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment
Journal of Clinical Neuroscience, Vol.25, pp.145-147
2016
Abstract
We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening in a 40-year-old patient with subsequent benign course with 12 months follow-up. The patient had a history of aggressive inflammatory multiple sclerosis, prior mitoxantrone therapy, Stratify John Cunningham Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and 5 years of natalizumab monotherapy. The initial MRI detection of PML was both atypical and subtle. Early diagnosis and intervention, and pre-emptive treatment for immune reconstitution inflammatory syndrome with high dose steroids, as well as empirical mirtazapine and mefloquine, were associated with a benign PML disease course and outcome.
Details
- Title
- Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment
- Authors/Creators
- M.J. Fabis-Pedrini (Author/Creator) - The University of Western AustraliaW. Xu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityJ. Burton (Author/Creator) - The University of Western AustraliaW.M. Carroll (Author/Creator) - The University of Western AustraliaA.G. Kermode (Author/Creator) - Murdoch University
- Publication Details
- Journal of Clinical Neuroscience, Vol.25, pp.145-147
- Publisher
- Churchill Livingstone
- Identifiers
- 991005542591107891
- Copyright
- © 2015 Elsevier Ltd.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.1385 Polyomavirus Oncogenesis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior