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Asymptotics of the allele frequency spectrum and the number of alleles
Journal article   Peer reviewed

Asymptotics of the allele frequency spectrum and the number of alleles

Ross A. Maller and Soudabeh Shemehsavar
Journal of applied probability, Early View
2024

Abstract

Allele frequency spectrum generalised Poisson–Dirichlet laws Ewens sampling formula Kingman’s Poisson–Dirichlet distributions Pitman sampling formula gene and species distributions
We derive large-sample and other limiting distributions of components of the allele frequency spectrum vector, $\mathbf{M}_n$ , joint with the number of alleles, $K_n$ , from a sample of n genes. Models analysed include those constructed from gamma and $\alpha$ -stable subordinators by Kingman (thus including the Ewens model), the two-parameter extension by Pitman and Yor, and a two-parameter version constructed by omitting large jumps from an $\alpha$ -stable subordinator. In each case the limiting distribution of a finite number of components of $\mathbf{M}_n$ is derived, joint with $K_n$ . New results include that in the Poisson–Dirichlet case, $\mathbf{M}_n$ and $K_n$ are asymptotically independent after centering and norming for $K_n$ , and it is notable, especially for statistical applications, that in other cases the limiting distribution of a finite number of components of $\mathbf{M}_n$ , after centering and an unusual $n^{\alpha/2}$ norming, conditional on that of $K_n$ , is normal.

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Collaboration types
Domestic collaboration
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Citation topics
9 Mathematics
9.50 Applied Statistics & Probability
9.50.372 Stochastic Processes
Web Of Science research areas
Statistics & Probability
ESI research areas
Mathematics
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