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Journal article
Australian Group on Antimicrobial Research surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 - December 2021
Communicable diseases intelligence (2018), Vol.48
2024
PMID: 39165021
Abstract
From 1 January 2020 to 31 December 2021, thirty-eight institutions across Australia submitted data to the Australian Group on Antimicrobial Resistance (AGAR) from patients aged < 18 years (AGAR-Kids). Over the two years, 1,679 isolates were reported from 1,611 patients. This AGAR-Kids report aims to describe the population of children and adolescents with bacteraemia reported to AGAR and the proportion of resistant isolates. Overall, there were 902 gram-negative isolates reported: 800 Enterobacterales, 61 Pseudomonas aeruginosa and 41 Acinetobacter spp. Among the Enterobacterales, 12.9% were resistant to third generation cephalosporins; 11.6% to gentamicin/tobramycin; and 11.2% to piperacillin-tazobactam. In total, 14.5% of Enterobacterales were multi-drug resistant (MDR). Only 3.3% of P. aeruginosa were resistant to carbapenems and 4.9% were MDR. Resistance in Acinetobacter spp was uncommon. Of 607 Staphylococcus aureus isolates, 12.9% were methicillin-resistant (MRSA). Almost half of S. aureus isolates from the Northern Territory were MRSA. In S. aureus, resistance to erythromycin was 13.2%; 12.4% to clindamycin; and 5.3% to ciprofloxacin. Resistance to all antibiotics tested was higher in MRSA. Overall, 6.5% of S. aureus were MDR, of which 65% were MRSA. Almost three-quarters of the 170 Enterococcus spp. reported were E. faecalis, and half were from patients < 1 year old. Ampicillin resistance in enterococci was 19.6%. Eight isolates were vancomycin resistant and three isolates were teicoplanin resistant. Five E. faecium isolates were classified as MDR. This AGAR-Kids report highlights clear differences in the geographic distribution of pathogens and resistance profiles across Australia.
Details
- Title
- Australian Group on Antimicrobial Research surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 - December 2021
- Authors/Creators
- Anita WilliamsGeoffrey W CoombsJan BellDenise A DaleyShakeel MowlaboccusPenelope A Bryant - Royal Children's HospitalAnita J Campbell - The University of Western AustraliaLouise Cooley - Royal Hobart HospitalJon IredellAdam D Irwin - The University of QueenslandAlison Kesson - Children's Hospital at WestmeadBrendan McMullan - Sydney Children’s Hospitals NetworkMorgyn S Warner - The University of AdelaidePhoebe Williams - UNSW SydneyChristoper C Blyth
- Publication Details
- Communicable diseases intelligence (2018), Vol.48
- Publisher
- Commonwealth of Australia, Department of Health and Aged Care
- Identifiers
- 991005695162307891
- Copyright
- © 2024 Commonwealth of Australia as represented by the Department of Health and Aged Care
- Murdoch Affiliation
- Centre for Biosecurity and One Health; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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