Journal article
Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Sepsis Outcome Programme (GNSOP) Annual Report 2017
Communicable Diseases Intelligence, Vol.43
2019
Abstract
The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric Gram-negative pathogens. The 2017 survey was the fifth year to focus on blood stream infections, and included Enterobacterales, Pseudomonas aeruginosa and Acinetobacter species.
Seven thousand nine hundred and ten isolates, comprising Enterobacterales (7,100, 89.8%), P. aer-uginosa (697, 8.8%) and Acinetobacter species (113, 1.4%), were tested using commercial automated methods. The results were analysed using Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints (January 2018). Of the key resistances, non-susceptibility to the third-generation cephalosporin, ceftriaxone, was found in 11.3%/11.3% of Escherichia coli (CLSI/EUCAST criteria), 8.8%/8.8% of Klebsiella pneu¬moniae, and 5.7%/5.7% of K. oxytoca. Non-susceptibility rates to ciprofloxacin were 12.1%/18.0% for E. coli, 4.4%/11.2% for K. pneumoniae, 1.3%/3.5% for K. oxytoca, 3.0%/8.5% for Enterobacter cloacae complex, and 5.1%/9.8% for P. aeruginosa. Resistance rates to piperacillin-tazobactam were 2.8%/5.9%, 3.7%/7.3%, 9.6%/11.0%, 22.5%/27.6%, and 6.4%/13.2% for the same five species respectively. Twenty-seven isolates from 25 patients were shown to harbour a carbapenemase gene: 12 bla IMP (11 patients), five bla OXA-181 (four patients), three bla OXA-23, two bla NDM, two bla KPC, two bla VIM, and one bla GES.
Details
- Title
- Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Sepsis Outcome Programme (GNSOP) Annual Report 2017
- Authors/Creators
- J.M. for the Australian Group on Antimicrobial Resistance Bell (Editor)T. Gottlieb (Editor) - Concord Repatriation General HospitalD.A. Daley (Editor) - Fiona Stanley HospitalG.W. Coombs (Editor) - Fiona Stanley Hospital
- Publication Details
- Communicable Diseases Intelligence, Vol.43
- Publisher
- Australian Government. Dept. of Health
- Identifiers
- 991005545083507891
- Copyright
- © 2019 Commonwealth of Australia as represented by the Department of Health
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
68 File views/ downloads
53 Record Views