Autism following a history of newborn encephalopathy: more than a coincidence?

Nadia Badawi; Glenys Dixon; Janine F Felix; John M Keogh; Beverly Petterson; Fiona J Stanley; Jennifer J Kurinczuk

doi:10.1017/S001216220600020X

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Autism following a history of newborn encephalopathy: more than a coincidence?

Journal article

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Peer reviewed

Autism following a history of newborn encephalopathy: more than a coincidence?

Nadia Badawi, Glenys Dixon, Janine F Felix, John M Keogh, Beverly Petterson, Fiona J Stanley and Jennifer J Kurinczuk

Developmental medicine and child neurology, Vol.48(2), pp.85-89

2006

DOI: https://doi.org/10.1017/S001216220600020X

PMID: 16417661

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Abstract

Between June 1993 and December 1996, 276 term newborn infants with encephalopathy and 564 randomly selected term controls were enrolled in a population-based study of moderate and severe term newborn encephalopathy (NE) in Western Australia. During comprehensive neurobehavioural and cognitive follow-up of all patients and controls at 3 years and again at 5 years of age we found an unexpected but strong association between NE and autism spectrum disorders (ASDs). A diagnosis of ASD by age 5 years was reached using criteria according of the Diagnostic Statistical Manual, 4th edition. Linking records to the Western Australian Disability Services Commission Register ensured that no child in the study with ASD was missed. By age 5 years, 37 (13.4%) infants with NE and one (0.2%) control had died. Among the 239 survivors of NE, 12 (5%) were diagnosed with an ASD. Of these, 10 (4.2%) met the full criteria for autism, one had pervasive developmental disorder–not otherwise specified, and one had Asperger syndrome. Among the 563 surviving controls, five (0.8%) were diagnosed with an ASD: three with autism, one with autism/possible Asperger syndrome, and one with Asperger syndrome. Compared with the controls, the children who had experienced NE were 5.9 times (95% confidence interval 2.0–16.9) more likely to have been diagnosed with an ASD.

Details

Title: Autism following a history of newborn encephalopathy: more than a coincidence?
Authors/Creators: Nadia Badawi - Children's Hospital at Westmead
Glenys Dixon - The Kids Research Institute Australia
Janine F Felix - Erasmus MC - Sophia Children’s Hospital
John M Keogh - The University of Sydney
Beverly Petterson - Hornsby Ku-ring-gai Hospital
Fiona J Stanley - The Kids Research Institute Australia
Jennifer J Kurinczuk - University of Oxford
Publication Details: Developmental medicine and child neurology, Vol.48(2), pp.85-89
Publisher: Cambridge University Press
Number of pages: 5
Identifiers: 991005570070707891
Murdoch Affiliation: Ngangk Yira Institute for Change
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.136 Autism & Development Disorders; 1.136.283 Autism Spectrum Disorders
Web Of Science research areas: Clinical Neurology; Pediatrics
ESI research areas: Neuroscience & Behavior