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Autoantibodies to pancreatic islet cells in canine diabetes mellitus
Journal article   Peer reviewed

Autoantibodies to pancreatic islet cells in canine diabetes mellitus

D.M. Haines and W.J. Penhale
Veterinary Immunology and Immunopathology, Vol.8(1-2), pp.149-156
1985
DOI: https://doi.org/10.1016/0165-2427(85)90118-7
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Abstract

Indirect immunofluorescence on normal canine pancreatic tissue fixed in Bouin's solution was used to detect islet cell antibodies in dogs with diabetes mellitus, other endocrine diseases, and pancreatitis. 18 of 25 dogs with diabetes mellitus alone, 2 of 8 dogs with diabetes mellitus and concurrent pancreatitis, and 2 of 2 dogs with diabetes mellitus and concurrent pancreatic exocrine insufficiency were positive for autoantibody. 2 of 12 dogs with hypoadrenocorticism, 3 of 6 dogs with hyperadrenocorticism, 6 of 28 dogs with hypothyroidism and one of 19 dogs with pancreatitis alone were also antibody positive. None of 20 healthy dogs or 20 dogs with disorders other than those of the pancreas or endocrine organs were antibody positive. Islet cell antibodies were demonstrated in dogs with diabetes mellitus and other endocrine disorders. The possibility of autoimmune involvement in the development of diabetes mellitus in the dog should be considered.

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Source: InCites

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9 Record Views
22 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.26 Diabetes
1.26.1016 Type 1 Diabetes
Web Of Science research areas
Immunology
Veterinary Sciences
ESI research areas
Plant & Animal Science
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