Journal article
Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
International Psychogeriatrics, Vol.26(10), pp.1737-1746
2014
Abstract
Background:
Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear.
Methods:
Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality.
Results:
Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) ɛ4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI.
Conclusions:
Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.
Details
- Title
- Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
- Authors/Creators
- R.F. Buckley (Author/Creator) - The University of MelbourneM.M. Saling (Author/Creator) - The University of MelbourneM. Irish (Author/Creator) - Neuroscience Research AustraliaD. Ames (Author/Creator) - The University of MelbourneC.C. Rowe (Author/Creator) - Department of Nuclear Medicine and Centre for PETV.L. Villemagne (Author/Creator) - Department of Nuclear Medicine and Centre for PETN.T. Lautenschlager (Author/Creator) - The University of MelbourneP. Maruff (Author/Creator) - The University of MelbourneS.L. Macaulay (Author/Creator) - Health Sciences and NutritionR.N. Martins (Author/Creator) - Edith Cowan UniversityC. Szoeke (Author/Creator) - National Institute on AgingC.L. Masters (Author/Creator) - The University of MelbourneS.R. Rainey-Smith (Author/Creator)A. Rembach (Author/Creator) - The University of MelbourneG. Savage (Author/Creator) - Macquarie UniversityK.A. Ellis (Author/Creator) - The University of Melbourne
- Publication Details
- International Psychogeriatrics, Vol.26(10), pp.1737-1746
- Publisher
- Cambridge University Press
- Identifiers
- 991005541668707891
- Copyright
- © 2014 International Psychogeriatric Association
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Geriatrics & Gerontology
- Gerontology
- Psychiatry
- Psychology
- Psychology, Clinical
- ESI research areas
- Psychiatry/Psychology