Aβ-related memory decline in APOE ε4 noncarriers

Y.Y. Lim; S.M. Laws; V.L. Villemagne; R.H. Pietrzak; T. Porter; D. Ames; C. Fowler; S. Rainey-Smith; P.J. Snyder; R.N. Martins; O. Salvado; P. Bourgeat; C.C. Rowe; C.L. Masters; P. Maruff

doi:10.1212/WNL.0000000000002604

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Aβ-related memory decline in APOE ε4 noncarriers

Journal article

Peer reviewed

Aβ-related memory decline in APOE ε4 noncarriers

Y.Y. Lim, S.M. Laws, V.L. Villemagne, R.H. Pietrzak, T. Porter, D. Ames, C. Fowler, S. Rainey-Smith, P.J. Snyder, R.N. Martins, …

Neurology, Vol.86(17), pp.1635-1642

2016

DOI: https://doi.org/10.1212/WNL.0000000000002604

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Abstract

Objective: As the absence of Aβ-related memory decline in APOE ε4 noncarriers may be due to the relative brevity of previous studies, we aimed to characterize Aβ-related cognitive decline over 72 months in APOE ε4 carriers and noncarriers who were cognitively normal (CN). Methods: CN older adults (n = 423) underwent Aβ imaging and APOE genotyping. Participants completed comprehensive neuropsychological testing at baseline 18-, 36-, 54-, and 72-month assessments. Results: Relative to Aβ− CN ε4 noncarriers, both Aβ+ CN ε4 carriers and noncarriers showed significantly increased decline in measures of memory, language, and executive function as well as higher rates of progression to a clinical classification of mild cognitive impairment. Memory decline was greater in Aβ+ CN ε4 carriers than in Aβ+ CN ε4 noncarriers. No cognitive decline was evident in Aβ− CN ε4 carriers. Conclusions: In CN older adults, Aβ+ is associated with memory decline in ε4 noncarriers; however, the rate of this decline is much slower than that observed in ε4 carriers. These data indicate that the processes by which ε4 carriage increases the rate of Aβ-related cognitive decline occur in the preclinical stage of Alzheimer disease.

Details

Title: Aβ-related memory decline in APOE ε4 noncarriers
Authors/Creators: Y.Y. Lim (Author/Creator) - The University of Melbourne
S.M. Laws (Author/Creator) - The University of Western Australia
V.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental Health
R.H. Pietrzak (Author/Creator) - Yale University
T. Porter (Author/Creator)
D. Ames (Author/Creator) - National Ageing Research Institute
C. Fowler (Author/Creator) - The University of Melbourne
S. Rainey-Smith (Author/Creator) - Carlton South, Cooperat Res Ctr Mental Hlth
P.J. Snyder (Author/Creator) - Brown University
R.N. Martins (Author/Creator) - Edith Cowan University
O. Salvado (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
P. Bourgeat (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
C.C. Rowe (Author/Creator) - Austin Health
C.L. Masters (Author/Creator) - The University of Melbourne
P. Maruff (Author/Creator) - Cogstate Ltd
Publication Details: Neurology, Vol.86(17), pp.1635-1642
Publisher: Lippincott Williams & Wilkins
Identifiers: 991005543580207891
Copyright: © 2016 American Academy of Neurology
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior