Aβ42/Aβ40 and Aβ42/Aβ38 ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer’s disease: A pilot study

I. Koychev; B. Galna; H. Zetterberg; J. Lawson; G. Zamboni; B.H. Ridha; J.B. Rowe; A. Thomas; R. Howard; P. Malhotra; C. Ritchie; S. Lovestone; L. Rochester

doi:10.3233/JAD-180622

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Aβ42/Aβ40 and Aβ42/Aβ38 ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer’s disease: A pilot study

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Aβ42/Aβ40 and Aβ42/Aβ38 ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer’s disease: A pilot study

I. Koychev, B. Galna, H. Zetterberg, J. Lawson, G. Zamboni, B.H. Ridha, J.B. Rowe, A. Thomas, R. Howard, P. Malhotra, …

Journal of Alzheimer's Disease, Vol.65(4), pp.1377-1383

2018

DOI: https://doi.org/10.3233/JAD-180622

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Abstract

Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer’s disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. CSF Aβ42/Aβ40 and Aβ42/Aβ38 correlated positively with measures of variability (step time and step length) in the clinic-based assessments. This was driven by a negative relationship between gait variability and Aβ40 and Aβ38 but not Aβ42.The amyloid ratios and gait variability measures were also associated with more severe functional impairment. We interpret these data as an indication that increasing amyloid production (i.e., increasing Aβ40 and Aβ38) is associated with diminishing cognitive-motor control of gait. These preliminary results suggest that the two amyloid ratios may be a marker of the earliest disturbances in the interplay between cognitive and motor control which characterize dementia.

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Title: Aβ42/Aβ40 and Aβ42/Aβ38 ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer’s disease: A pilot study
Authors/Creators: I. Koychev (Author/Creator)
B. Galna (Author/Creator)
H. Zetterberg (Author/Creator)
J. Lawson (Author/Creator)
G. Zamboni (Author/Creator)
B.H. Ridha (Author/Creator)
J.B. Rowe (Author/Creator)
A. Thomas (Author/Creator)
R. Howard (Author/Creator)
P. Malhotra (Author/Creator)
C. Ritchie (Author/Creator)
S. Lovestone (Author/Creator)
L. Rochester (Author/Creator)
Publication Details: Journal of Alzheimer's Disease, Vol.65(4), pp.1377-1383
Publisher: IOS Press and the authors
Identifiers: 991005541765807891
Copyright: © 2018 – IOS Press
Murdoch Affiliation: Centre for Healthy Ageing; Murdoch University; School of Allied Health
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior