Journal article
B cell depleting therapy for multiple sclerosis overlapping with neuromyelitis optica spectrum disorder
Multiple Sclerosis and Related Disorders, Vol.22, pp.83-85
2018
Abstract
Multiple sclerosis and neuromyelitis optica spectrum disorder are currently thought to be independent entities. Some patients display intermediate manifestations that fit the criteria for both diseases without positive relevant serobiomarkers. An overall standard and consensus for the diagnosis and treatment of these overlapping patients have not been reached. We describe a patient with frequently relapsing demyelinating episodes and repeatedly adjusted treatment regimens due to diagnostic difficulties. This case did not respond adequately to glucocorticoid plus azathioprine or to interferon. Benefits were finally obtained by using rituximab, an anti-CD20 specific monoclonal antibody targeting B cells. Treatments targeting B cell mediated humoral immunity such as rituximab, may be a safe and appropriate choice for these challenging demyelinating cases, especially in Asian population.
Details
- Title
- B cell depleting therapy for multiple sclerosis overlapping with neuromyelitis optica spectrum disorder
- Authors/Creators
- T. Lu (Author/Creator)Y. Shu (Author/Creator)Y. Dai (Author/Creator)X. Liu (Author/Creator)Y. Chang (Author/Creator)Q. Huang (Author/Creator)A.G. Kermode (Author/Creator)W. Qiu (Author/Creator)
- Publication Details
- Multiple Sclerosis and Related Disorders, Vol.22, pp.83-85
- Publisher
- Elsevier B.V.
- Identifiers
- 991005545059407891
- Copyright
- © 2018 Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior