Journal article
BOC-CCK-4, CCKB receptor agonist, antagonizes anxiolytic-like action of morphine in elevated plus-maze
Neuropeptides, Vol.33(1), pp.63-69
1999
Abstract
This study investigated a role of cholecystokinin (CCK) in the anxiolytic-like action of morphine, an agonist of μ-opioid receptors, in the rat plus-maze model of anxiety. The acute administration of morphine (1 mg/kg) induced a significant increase of exploratory activity in the plus-maze, but did not affect the locomotor activity in the motility test. The higher dose of morphine (2.5 mg/kg) tended to decrease the locomotor activity and, therefore, did not cause the anxiolytic-like action in the plus-maze. The other drugs (naloxone, BOC-CCK-4, L-365,260) and their combinations with morphine (0.5–1 mg/kg) did not affect the locomotor activity of rats. The opioid antagonist naloxone itself (0.5 mg/kg) did not change the exploratory activity in the plus-maze, but potently antagonized the anxiolytic-like action of morphine (1 mg/kg). An agonist of CCKBreceptors BOC-CCK-4 (1–50 μg/kg) induced a dose-dependent anxiogenic-like action in the plus-maze. Nevertheless, only one dose of BOC-CCK-4 (10 μg/kg) completely reversed the action of morphine. Also, one dose of CCKBreceptor antagonist L-365,260 (10 μg/kg) was effective to modify the behaviour of rats in the elevated plus-maze. Namely, this dose of L-365,260 increased the ratio between open and total arm entries, a behavioural measure believed to reflect the anxiolytic-like action in the elevated plus-maze. The combination of L-365,260 (100 μg/kg) with the sub-effective dose of morphine (0.5 mg/kg) caused the anxiolytic-like action in the plus-maze not seen if the drugs were given alone. In conclusion, morphine induces a potent anxiolytic-like action in the elevated plus-maze and CCK is acting as an endogenous antagonist of this effect of morphine.
Details
- Title
- BOC-CCK-4, CCKB receptor agonist, antagonizes anxiolytic-like action of morphine in elevated plus-maze
- Authors/Creators
- S. Kõks (Author/Creator) - University of TartuA. Soosaar (Author/Creator) - University of TartuV. Võikar (Author/Creator) - University of TartuM. Bourin (Author/Creator) - Nantes UniversitéE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Neuropeptides, Vol.33(1), pp.63-69
- Publisher
- Elsevier
- Identifiers
- 991005541120207891
- Copyright
- © 1999 Harcourt Publishers Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.195 Neuroendocrine & Intestinal Disorders
- 1.195.1096 Gastrin/CCK Functions
- Web Of Science research areas
- Endocrinology & Metabolism
- Neurosciences
- ESI research areas
- Neuroscience & Behavior