Journal article
Babesia gibsoni: Detection during experimental infections and after combined atovaquone and azithromycin therapy
Experimental Parasitology, Vol.117(2), pp.115-123
2007
Abstract
Babesia gibsoni is a protozoan parasite of dogs worldwide yet both an effective treatment and a reliable method for detecting subclinical cases of this emerging infection remain elusive. Experimental B. gibsoni infections were established in vivo to investigate the efficacy of combined atovaquone and azithromycin drug therapy and to determine the detection limits of a nested-PCR, IFAT and microscopy during various stages of infection. While atovaquone and azithromycin produced a reduction in parasitaemia, it did not eliminate the parasite and drug resistance appeared to develop in one dog. Polymerase chain reaction was found to be most useful in detecting infection in the pre-acute and acute stages, while IFAT was most reliable during chronic infections. Microscopy is suggested to be only effective for detecting acute stage infections. This study also describes the detection of B. gibsoni in tissue samples during chronic infections for the first time, suggesting possible sequestration of this parasite.
Details
- Title
- Babesia gibsoni: Detection during experimental infections and after combined atovaquone and azithromycin therapy
- Authors/Creators
- R. Jefferies (Author/Creator) - Murdoch UniversityU.M. Ryan (Author/Creator) - Murdoch UniversityJ. Jardine (Author/Creator) - VETPATH Laboratory Services, Ascot, WA 6104, AustraliaI.D. Robertson (Author/Creator) - Murdoch UniversityP.J. Irwin (Author/Creator) - Murdoch University
- Publication Details
- Experimental Parasitology, Vol.117(2), pp.115-123
- Publisher
- Academic Press
- Identifiers
- 991005542691907891
- Copyright
- © 2007 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.258 Zoonotic Diseases
- 1.258.227 Tick-borne Pathogens
- Web Of Science research areas
- Parasitology
- ESI research areas
- Microbiology