Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs

Angela Boahen; Dailun Hu; Murray J. Adams; Philip K. Nicholls; Wayne K. Greene; Bin Ma

doi:10.3389/fimmu.2023.1254054

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Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs

Journal article

Open access

Peer reviewed

Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs

Angela Boahen, Dailun Hu, Murray J. Adams, Philip K. Nicholls, Wayne K. Greene and Bin Ma

Frontiers in immunology, Vol.14, 1254054

2023

DOI: https://doi.org/10.3389/fimmu.2023.1254054

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Abstract

Immunology

The central nervous system (CNS) influences the immune system generally by regulating the systemic concentration of humoral substances (e.g., cortisol and epinephrine), whereas the peripheral nervous system (PNS) communicates specifically with the immune system according to local interactions/connections. An imbalance between the components of the PNS might contribute to pathogenesis and the further development of certain diseases. In this review, we have explored the “thread” (hardwiring) of the connections between the immune system (e.g., primary/secondary/tertiary lymphoid tissues/organs) and PNS (e.g., sensory, sympathetic, parasympathetic, and enteric nervous systems (ENS)) in health and disease in vitro and in vivo . Neuroimmune cell units provide an anatomical and physiological basis for bidirectional crosstalk between the PNS and the immune system in peripheral tissues, including lymphoid tissues and organs. These neuroimmune interactions/modulation studies might greatly contribute to a better understanding of the mechanisms through which the PNS possibly affects cellular and humoral-mediated immune responses or vice versa in health and diseases. Physical, chemical, pharmacological, and other manipulations of these neuroimmune interactions should bring about the development of practical therapeutic applications for certain neurological, neuroimmunological, infectious, inflammatory, and immunological disorders/diseases.

Details

Title: Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs
Authors/Creators: Angela Boahen - Universiti Putra Malaysia
Dailun Hu - Hebei Medical University
Murray J. Adams - Murdoch University
Philip K. Nicholls - Murdoch University
Wayne K. Greene - Murdoch University
Bin Ma - Murdoch University
Publication Details: Frontiers in immunology, Vol.14, 1254054
Publisher: Frontiers Media S.A
Identifiers: 991005606069007891
Copyright: © 2023 Boahen, Hu, Adams, Nicholls, Greene and Ma
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.5 Neuroscience; 1.5.894 Nicotinic Receptors
Web Of Science research areas: Immunology
ESI research areas: Immunology