Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

J.C. Huh; D.H. Strickland; F.L. Jahnsen; D.J. Turner; J.A. Thomas; S. Napoli; I. Tobagus; P.A. Stumbles; P.D. Sly; P.G. Holt

doi:10.1084/jem.20021328

Back

Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

Journal article

Open access

Peer reviewed

Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

J.C. Huh, D.H. Strickland, F.L. Jahnsen, D.J. Turner, J.A. Thomas, S. Napoli, I. Tobagus, P.A. Stumbles, P.D. Sly and P.G. Holt

Journal of Experimental Medicine, Vol.198(1), pp.19-30

2003

DOI: https://doi.org/10.1084/jem.20021328

Files and links (2)

pdf

Bidirectional_Interactions.pdfDownload View

Published (Version of Record) Open Access

url

Link to Published Version *Subscription may be requiredView

Abstract

The airway mucosal response to allergen in asthma involves influx of activated T helper type 2 cells and eosinophils, transient airflow obstruction, and airways hyperresponsiveness (AHR). The mechanism(s) underlying transient T cell activation during this inflammatory response is unclear. We present evidence that this response is regulated via bidirectional interactions between airway mucosal dendritic cells (AMDC) and T memory cells. After aerosol challenge, resident AMDC acquire antigen and rapidly mature into potent antigen-presenting cells (APCs) after cognate interactions with T memory cells. This process is restricted to dendritic cells (DCs) in the mucosae of the conducting airways, and is not seen in peripheral lung. Within 24 h, antigen-bearing mature DCs disappear from the airway wall, leaving in their wake activated interleukin 2R+ T cells and AHR. Antigen-bearing activated DCs appear in regional lymph nodes at 24 h, suggesting onward migration from the airway. Transient up-regulation of CD86 on AMDC accompanies this process, which can be reproduced by coculture of resting AMDC with T memory cells plus antigen. The APC activity of AMDC can be partially inhibited by anti-CD86, suggesting that CD86 may play an active role in this process and/or is a surrogate for other relevant costimulators. These findings provide a plausible model for local T cell activation at the lesional site in asthma, and for the transient nature of this inflammatory response.

Details

Title: Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma
Authors/Creators: J.C. Huh (Author/Creator) - The Kids Research Institute Australia
D.H. Strickland (Author/Creator) - The Kids Research Institute Australia
F.L. Jahnsen (Author/Creator) - The Kids Research Institute Australia
D.J. Turner (Author/Creator) - The Kids Research Institute Australia
J.A. Thomas (Author/Creator) - The Kids Research Institute Australia
S. Napoli (Author/Creator) - The Kids Research Institute Australia
I. Tobagus (Author/Creator) - The Kids Research Institute Australia
P.A. Stumbles (Author/Creator) - The Kids Research Institute Australia
P.D. Sly (Author/Creator) - The Kids Research Institute Australia
P.G. Holt (Author/Creator) - The Kids Research Institute Australia
Publication Details: Journal of Experimental Medicine, Vol.198(1), pp.19-30
Publisher: The Rockefeller University Press
Identifiers: 991005542868507891
Copyright: 2003 Rockefeller University Press
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

231 File views/ downloads

54 Record Views

154 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.358 Dendritic Cell Therapy
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology