Journal article
Biochemical changes within a multiple sclerosis plaque in vivo
Journal of Neurology, Neurosurgery & Psychiatry, Vol.54(11), pp.1004-1006
1991
Abstract
Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing a large multiple sclerosis (MS) lesion. Reduced levels of phosphocreatine (PCr) relative to adenosine triphosphate (ATP) were found suggesting an abnormality in energy metabolism, with an increase in the phosphodiester (PDE) peak. A follow up study 16 months later revealed reduction in size of the lesion on MRI and normal intracellular biochemistry by MRS. Four MS patients without visible superficial cerebral lesions showed no significant changes in phosphorus metabolism.
Details
- Title
- Biochemical changes within a multiple sclerosis plaque in vivo
- Authors/Creators
- T.A. Cadoux-Hudson (Author/Creator) - John Radcliffe HospitalA. Kermode (Author/Creator) - Oxford University Hospitals NHS TrustB. Rajagopalan (Author/Creator)D. Taylor (Author/Creator)A.J. Thompson (Author/Creator)I.E. Ormerod (Author/Creator)W.I. McDonald (Author/Creator)G.K. Radda (Author/Creator)
- Publication Details
- Journal of Neurology, Neurosurgery & Psychiatry, Vol.54(11), pp.1004-1006
- Publisher
- BMJ Publishing Group
- Identifiers
- 991005544322207891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.113 Brain Imaging
- 1.113.1394 Magnetic Resonance Spectroscopy
- Web Of Science research areas
- Clinical Neurology
- Psychiatry
- Surgery
- ESI research areas
- Clinical Medicine