Journal article
Biogenic Au@ZnO core–shell nanocomposites kill Staphylococcus aureus without provoking nuclear damage and cytotoxicity in mouse fibroblasts cells under hyperglycemic condition with enhanced wound healing proficiency
Medical Microbiology and Immunology, Vol.208(5), pp.609-629
2018
Abstract
The aim of the present study is focused on the synthesis of Au@ZnO core–shell nanocomposites, where zinc oxide is overlaid on biogenic gold nanoparticles obtained from Hibiscus Sabdariffa plant extract. Optical property of nanocomposites is investigated using UV–visible spectroscopy and crystal structure has been determined using X-ray crystallography (XRD) technique. The presence of functional groups on the surface of Au@ZnO core–shell nanocomposites has been observed by Fourier transforms infrared (FTIR) spectroscopy. Electron microscopy studies revealed the morphology of the above core–shell nanocomposites. The synthesized nanocomposite material has shown antimicrobial and anti-biofilm activity against Staphylococcus aureus and Methicillin Resistant Staphylococcus haemolyticus (MRSH). The microbes are notorious cross contaminant and are known to cause infection in open wounds. The possible antimicrobial mechanism of as synthesized nanomaterials has been investigated against Staphylococcus aureus and obtained data suggests that the antimicrobial activity could be due to release of reactive oxygen species (ROS). Present study has revealed that surface varnishing of biosynthesized gold nanoparticles through zinc oxide has improved its antibacterial proficiency against Staphylococcus aureus, whereas reducing its toxic effect towards mouse fibroblast cells under normal and hyperglycaemic condition. Further studies have been performed in mice model to understand the wound healing efficiency of Au@ZnO nanocomposites. The results obtained suggest the possible and effective use of as synthesized core shell nanocomposites in wound healing.
Details
- Title
- Biogenic Au@ZnO core–shell nanocomposites kill Staphylococcus aureus without provoking nuclear damage and cytotoxicity in mouse fibroblasts cells under hyperglycemic condition with enhanced wound healing proficiency
- Authors/Creators
- M.I. Khan (Author/Creator) - KIIT UniversityS.K. Behera (Author/Creator) - IMGENEX India (India)P. Paul (Author/Creator) - KIIT UniversityB. Das (Author/Creator) - National Institute of Technology RourkelaM. Suar (Author/Creator) - KIIT UniversityR. Jayabalan (Author/Creator) - National Institute of Technology RourkelaD. Fawcett (Author/Creator) - Murdoch UniversityG.E.J. Poinern (Author/Creator) - Murdoch UniversityS.K. Tripathy (Author/Creator) - KIIT UniversityA. Mishra (Author/Creator) - KIIT University
- Publication Details
- Medical Microbiology and Immunology, Vol.208(5), pp.609-629
- Publisher
- Springer
- Identifiers
- 991005543030707891
- Copyright
- © 2018, Springer-Verlag GmbH Germany, part of Springer Nature
- Murdoch Affiliation
- School of Engineering and Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.67 Nanoparticles
- 2.67.231 Nanotoxicology
- Web Of Science research areas
- Immunology
- Microbiology
- ESI research areas
- Immunology