Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus originating from a healthy Eurasian coot

S. Shan; T.M. Ellis; S. Fenwick; J. Edwards; M. O’Dea; J. Parkinson

doi:10.1007/s00705-010-0588-1

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Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus originating from a healthy Eurasian coot

Journal article

Peer reviewed

Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus originating from a healthy Eurasian coot

S. Shan, T.M. Ellis, S. Fenwick, J. Edwards, M. O’Dea and J. Parkinson

Archives of Virology, Vol.155(3), pp.403-409

2010

DOI: https://doi.org/10.1007/s00705-010-0588-1

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Abstract

Influenza A virus, A/Eurasian coot/Western Australia/2727/79 (H6N2), from an apparently healthy coot was characterized. This virus was able to grow on MDCK cells and produce a cytopathic effect in the absence of exogenous trypsin and was further characterized as a low-pathogenicity avian influenza virus, with an intravenous pathogenicity index of 0.15 and a 321PQAETRG328 motif at the cleavage site of the haemagglutinin gene. It infected domestic chickens, resulting in seroconversion and intermittent virus excretion via cloaca and oropharynx under experimental conditions. Phylogenetic analysis showed that the viral genes were closely related to other waterfowl isolates from the same geographic area and time period.

Details

Title: Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus originating from a healthy Eurasian coot
Authors/Creators: S. Shan (Author/Creator) - Murdoch University
T.M. Ellis (Author/Creator) - Murdoch University
S. Fenwick (Author/Creator) - Murdoch University
J. Edwards (Author/Creator) - Murdoch University
M. O’Dea (Author/Creator) - Agriculture and Food
J. Parkinson (Author/Creator) - Agriculture and Food
Publication Details: Archives of Virology, Vol.155(3), pp.403-409
Publisher: Springer Verlag
Identifiers: 991005541132007891
Copyright: © 2010 Springer-Verlag
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.126 Influenza
Web Of Science research areas: Virology
ESI research areas: Microbiology